A rabbit model to study orbital venous pressure, intraocular pressure, and ocular hemodynamics simultaneously

Herbert A. Reitsamer, Jeffrey W. Kiel

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


PURPOSE. To measure orbital venous pressure (OVP) and determine the effects of changes in mean arterial pressure (MAP) on OVP, intraocular pressure (IOP), episcleral venous pressure (EVP), and ciliary and choroidal blood flows. METHODS. The experiments were performed in anesthetized rabbits. In all animals, MAP, IOP, and OVP were measured by direct cannulation of the central ear artery, the vitreous, and the orbital venous sinus, respectively. Laser Doppler flowmetry was used to measure choroidal blood flow in one group, and ciliary blood flow in a second group. A servonull micropressure system was used to measure EVP in a third group. The protocol for all three groups entailed varying MAP mechanically with occluders on the aorta and vena cava. RESULTS. The OVP and IOP relationship correlated linearly (r = 0.99) during mechanical manipulation of MAP. EVP also correlated well with OVP (r = 0.9). Resistance calculations based on choroidal and ciliary blood flows and the pressure gradients indicate active adjustment of arterial resistance and passive changes in venous resistance in response to changing MAP in both circulations. CONCLUSIONS. The rabbit orbital venous sinus permits continuous measurements of OVP. The present findings show that OVP is not static and suggest that OVP may play an important role in IOP homeostasis and ocular hemodynamics.

Original languageEnglish (US)
Pages (from-to)3728-3734
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Issue number12
StatePublished - Dec 1 2002

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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