A quantitative trait locus on chromosome 22 for serum leptin levels adjusted for serum testosterone

Lisa J. Martin, Michael C. Mahaney, Laura Almasy, James E. Hixson, Shelley A. Cole, Jean W. MacCluer, Cashell E. Jaquish, John Blangero, Anthony G. Comuzzie

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Objective: Studies have reported the existence of marked sexual dimorphism in serum leptin levels in humans with women having approximately two to three times the levels of men. We have shown that this sexual dimorphism has a strong genetic component arising from a genotype by sex interaction, but adjusting leptin levels for testosterone eliminates this interaction. Because interactions such as genotype X sex can confound the detection of quantitative trait loci (QTLs), we wanted to determine if there are QTLs associated with the expression of leptin adjusted for testosterone. Research Methods and Procedures: We performed a genome-wide scan using multipoint linkage analysis and implemented a general pedigree-based variance-component approach to identify genes with measurable effects on variation in leptin levels independent of testosterone in 318 Mexican Americans from the San Antonio Family Heart Study. Results: We detected significant evidence of linkage (log of the odds ratio = 3.44) for a QTL on chromosome 22. Discussion: Given these results, we hypothesize that a QTL on chromosome 22 may influence the level of leptin adjusted for testosterone.

Original languageEnglish (US)
Pages (from-to)602-607
Number of pages6
JournalObesity Research
Issue number7
StatePublished - Jul 2002
Externally publishedYes


  • Obesity
  • Sex hormones
  • Variance component linkage analysis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Public Health, Environmental and Occupational Health


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