A quantitative trait locus influencing type 2 diabetes susceptibility maps to a region on 5q in an extended French family

Lisa J. Martin, Anthony G. Comuzzie, Sophie Dupont, Nathalie Vionnet, Christian Dina, Sophie Gallina, Mouna Houari, John Blangero, Philippe Froguel

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Type 2 diabetes is a heterogeneous disorder of glucose metabolism characterized by insulin resistance, β-cell dysfunction, and increased glucose production by the liver. Given the high degree of genetic heterogeneity, multiple genes with small to moderate effects may influence susceptibility to diabetes. To circumvent this limitation, we searched for quantitative trait loci (QTLs) that explain the variation in susceptibility of type 2 diabetes in a single extended family, as these individuals are likely to share polymorphisms. We collected genotypic and phenotypic data on 152 individuals ascertained through a multimedia campaign in France to find diabetes-prone families for genetic studies. The effects of genes and covariates (age and sex) on diabetes status were estimated using a threshold model and a maximum likelihood variance component approach. We obtained suggestive evidence of linkage (logarithm of odds [LOD] = 2.4) for diabetes status on chromosome 5q. Within the 1-LOD unit support interval, there are two strong candidates: PCSK1 and CAST. Furthermore, we have obtained a replication (LOD = 1.6) for a QTL for type 2 diabetes on chromosome 11 detected by Hanson and colleagues (1998).

Original languageEnglish (US)
Pages (from-to)3568-3572
Number of pages5
JournalDiabetes
Volume51
Issue number12
StatePublished - Dec 1 2002
Externally publishedYes

Fingerprint

Quantitative Trait Loci
Type 2 Diabetes Mellitus
Glucose Metabolism Disorders
Chromosomes, Human, Pair 11
Multimedia
Genetic Heterogeneity
Genes
France
Insulin Resistance
Chromosomes
Glucose
Liver

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Martin, L. J., Comuzzie, A. G., Dupont, S., Vionnet, N., Dina, C., Gallina, S., ... Froguel, P. (2002). A quantitative trait locus influencing type 2 diabetes susceptibility maps to a region on 5q in an extended French family. Diabetes, 51(12), 3568-3572.

A quantitative trait locus influencing type 2 diabetes susceptibility maps to a region on 5q in an extended French family. / Martin, Lisa J.; Comuzzie, Anthony G.; Dupont, Sophie; Vionnet, Nathalie; Dina, Christian; Gallina, Sophie; Houari, Mouna; Blangero, John; Froguel, Philippe.

In: Diabetes, Vol. 51, No. 12, 01.12.2002, p. 3568-3572.

Research output: Contribution to journalArticle

Martin, LJ, Comuzzie, AG, Dupont, S, Vionnet, N, Dina, C, Gallina, S, Houari, M, Blangero, J & Froguel, P 2002, 'A quantitative trait locus influencing type 2 diabetes susceptibility maps to a region on 5q in an extended French family', Diabetes, vol. 51, no. 12, pp. 3568-3572.
Martin LJ, Comuzzie AG, Dupont S, Vionnet N, Dina C, Gallina S et al. A quantitative trait locus influencing type 2 diabetes susceptibility maps to a region on 5q in an extended French family. Diabetes. 2002 Dec 1;51(12):3568-3572.
Martin, Lisa J. ; Comuzzie, Anthony G. ; Dupont, Sophie ; Vionnet, Nathalie ; Dina, Christian ; Gallina, Sophie ; Houari, Mouna ; Blangero, John ; Froguel, Philippe. / A quantitative trait locus influencing type 2 diabetes susceptibility maps to a region on 5q in an extended French family. In: Diabetes. 2002 ; Vol. 51, No. 12. pp. 3568-3572.
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