A quantitative trait locus influencing estrogen levels maps to a region homologous to human chromosome 20

Lisa J. Martin, John Blangero, Jeffrey Rogers, Michael C. Mahaney, James E. Hixson, K. Dee Carey, Phillip A. Morin, Anthony G. Comuzzie

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

A quantitative trait locus influencing estrogen levels maps to a region homologous to human chromosome 20. Physiol Genomics 5: 75-80, 2001. - Estrogen, a steroid hormone, regulates reproduction and has been implicated in several diseases. We performed a genome-wide scan using multipoint linkage analysis implemented in a general pedigree-based variance component approach to identify genes with measurable effects on variation in estrogen levels in baboons. A microsatellite polymorphism, D20S171, located on human chromosome 20q13.11, showed strong evidence of linkage with a LOD score of 3.06 (P = 0.00009). This region contains several potential candidate genes including melanocortin 3 receptor (MC3R), cytochrome P-450 subfamily XXIV (CYP24), and breast carcinoma amplified sequence (BCAS1). This is the first evidence of a quantitative trait locus with a significant effect on estrogen.

Original languageEnglish (US)
Pages (from-to)75-80
Number of pages6
JournalPhysiological Genomics
Volume2001
Issue number5
StatePublished - Jun 2001
Externally publishedYes

Keywords

  • Baboons
  • Reproductive hormones
  • Variance component linkage analysis

ASJC Scopus subject areas

  • Physiology
  • Genetics

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