A quantitative trait locus influencing estrogen levels maps to a region homologous to human chromosome 20

Lisa J. Martin; John Blangero; Jeffrey Rogers; Michael C. Mahaney; James E. Hixson; K. Dee Carey; Phillip A. Morin; Anthony G. Comuzzie

A quantitative trait locus influencing estrogen levels maps to a region homologous to human chromosome 20

Lisa J. Martin, John Blangero, Jeffrey Rogers, Michael C. Mahaney, James E. Hixson, K. Dee Carey, Phillip A. Morin, Anthony G. Comuzzie

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A quantitative trait locus influencing estrogen levels maps to a region homologous to human chromosome 20. Physiol Genomics 5: 75-80, 2001. - Estrogen, a steroid hormone, regulates reproduction and has been implicated in several diseases. We performed a genome-wide scan using multipoint linkage analysis implemented in a general pedigree-based variance component approach to identify genes with measurable effects on variation in estrogen levels in baboons. A microsatellite polymorphism, D20S171, located on human chromosome 20q13.11, showed strong evidence of linkage with a LOD score of 3.06 (P = 0.00009). This region contains several potential candidate genes including melanocortin 3 receptor (MC3R), cytochrome P-450 subfamily XXIV (CYP24), and breast carcinoma amplified sequence (BCAS1). This is the first evidence of a quantitative trait locus with a significant effect on estrogen.

Original language	English (US)
Pages (from-to)	75-80
Number of pages	6
Journal	Physiological Genomics
Volume	2001
Issue number	5
State	Published - Jun 2001
Externally published	Yes

Keywords

Baboons
Reproductive hormones
Variance component linkage analysis

ASJC Scopus subject areas

Physiology
Genetics

Cite this

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title = "A quantitative trait locus influencing estrogen levels maps to a region homologous to human chromosome 20",

abstract = "A quantitative trait locus influencing estrogen levels maps to a region homologous to human chromosome 20. Physiol Genomics 5: 75-80, 2001. - Estrogen, a steroid hormone, regulates reproduction and has been implicated in several diseases. We performed a genome-wide scan using multipoint linkage analysis implemented in a general pedigree-based variance component approach to identify genes with measurable effects on variation in estrogen levels in baboons. A microsatellite polymorphism, D20S171, located on human chromosome 20q13.11, showed strong evidence of linkage with a LOD score of 3.06 (P = 0.00009). This region contains several potential candidate genes including melanocortin 3 receptor (MC3R), cytochrome P-450 subfamily XXIV (CYP24), and breast carcinoma amplified sequence (BCAS1). This is the first evidence of a quantitative trait locus with a significant effect on estrogen.",

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T1 - A quantitative trait locus influencing estrogen levels maps to a region homologous to human chromosome 20

AU - Martin, Lisa J.

AU - Blangero, John

AU - Rogers, Jeffrey

AU - Mahaney, Michael C.

AU - Hixson, James E.

AU - Carey, K. Dee

AU - Morin, Phillip A.

AU - Comuzzie, Anthony G.

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AB - A quantitative trait locus influencing estrogen levels maps to a region homologous to human chromosome 20. Physiol Genomics 5: 75-80, 2001. - Estrogen, a steroid hormone, regulates reproduction and has been implicated in several diseases. We performed a genome-wide scan using multipoint linkage analysis implemented in a general pedigree-based variance component approach to identify genes with measurable effects on variation in estrogen levels in baboons. A microsatellite polymorphism, D20S171, located on human chromosome 20q13.11, showed strong evidence of linkage with a LOD score of 3.06 (P = 0.00009). This region contains several potential candidate genes including melanocortin 3 receptor (MC3R), cytochrome P-450 subfamily XXIV (CYP24), and breast carcinoma amplified sequence (BCAS1). This is the first evidence of a quantitative trait locus with a significant effect on estrogen.

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KW - Reproductive hormones

KW - Variance component linkage analysis

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A quantitative trait locus influencing estrogen levels maps to a region homologous to human chromosome 20

Abstract

Keywords

ASJC Scopus subject areas

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