A quantitative trait locus influencing estrogen levels maps to a region homologous to human chromosome 20

Lisa J. Martin, John Blangero, Jeffrey Rogers, Michael C. Mahaney, James E. Hixson, K. Dee Carey, Phillip A. Morin, Anthony G. Comuzzie

    Research output: Contribution to journalArticle

    13 Scopus citations

    Abstract

    A quantitative trait locus influencing estrogen levels maps to a region homologous to human chromosome 20. Physiol Genomics 5: 75-80, 2001. - Estrogen, a steroid hormone, regulates reproduction and has been implicated in several diseases. We performed a genome-wide scan using multipoint linkage analysis implemented in a general pedigree-based variance component approach to identify genes with measurable effects on variation in estrogen levels in baboons. A microsatellite polymorphism, D20S171, located on human chromosome 20q13.11, showed strong evidence of linkage with a LOD score of 3.06 (P = 0.00009). This region contains several potential candidate genes including melanocortin 3 receptor (MC3R), cytochrome P-450 subfamily XXIV (CYP24), and breast carcinoma amplified sequence (BCAS1). This is the first evidence of a quantitative trait locus with a significant effect on estrogen.

    Original languageEnglish (US)
    Pages (from-to)75-80
    Number of pages6
    JournalPhysiological Genomics
    Volume2001
    Issue number5
    StatePublished - Jun 1 2001

      Fingerprint

    Keywords

    • Baboons
    • Reproductive hormones
    • Variance component linkage analysis

    ASJC Scopus subject areas

    • Physiology
    • Genetics

    Cite this

    Martin, L. J., Blangero, J., Rogers, J., Mahaney, M. C., Hixson, J. E., Carey, K. D., Morin, P. A., & Comuzzie, A. G. (2001). A quantitative trait locus influencing estrogen levels maps to a region homologous to human chromosome 20. Physiological Genomics, 2001(5), 75-80.