A quantitative trait locus influencing estrogen levels maps to a region homologous to human chromosome 20.

L. J. Martin, J. Blangero, J. Rogers, M. C. Mahaney, J. E. Hixson, K. D. Carey, P. A. Morin, A. G. Comuzzie

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Estrogen, a steroid hormone, regulates reproduction and has been implicated in several diseases. We performed a genome-wide scan using multipoint linkage analysis implemented in a general pedigree-based variance component approach to identify genes with measurable effects on variation in estrogen levels in baboons. A microsatellite polymorphism, D20S171, located on human chromosome 20q13.11, showed strong evidence of linkage with a LOD score of 3.06 (P = 0.00009). This region contains several potential candidate genes including melanocortin 3 receptor (MC3R), cytochrome P-450 subfamily XXIV (CYP24), and breast carcinoma amplified sequence (BCAS1). This is the first evidence of a quantitative trait locus with a significant effect on estrogen.

Original languageEnglish (US)
Pages (from-to)75-80
Number of pages6
JournalPhysiol Genomics
Volume5
Issue number2
StatePublished - Mar 8 2001
Externally publishedYes

Fingerprint

Chromosomes, Human, Pair 20
Quantitative Trait Loci
Human Chromosomes
Estrogens
Receptor, Melanocortin, Type 3
Papio
Pedigree
Microsatellite Repeats
Cytochrome P-450 Enzyme System
Genes
Reproduction
Steroids
Genome
Hormones
Breast Neoplasms

ASJC Scopus subject areas

  • Physiology
  • Genetics

Cite this

Martin, L. J., Blangero, J., Rogers, J., Mahaney, M. C., Hixson, J. E., Carey, K. D., ... Comuzzie, A. G. (2001). A quantitative trait locus influencing estrogen levels maps to a region homologous to human chromosome 20. Physiol Genomics, 5(2), 75-80.

A quantitative trait locus influencing estrogen levels maps to a region homologous to human chromosome 20. / Martin, L. J.; Blangero, J.; Rogers, J.; Mahaney, M. C.; Hixson, J. E.; Carey, K. D.; Morin, P. A.; Comuzzie, A. G.

In: Physiol Genomics, Vol. 5, No. 2, 08.03.2001, p. 75-80.

Research output: Contribution to journalArticle

Martin, LJ, Blangero, J, Rogers, J, Mahaney, MC, Hixson, JE, Carey, KD, Morin, PA & Comuzzie, AG 2001, 'A quantitative trait locus influencing estrogen levels maps to a region homologous to human chromosome 20.', Physiol Genomics, vol. 5, no. 2, pp. 75-80.
Martin LJ, Blangero J, Rogers J, Mahaney MC, Hixson JE, Carey KD et al. A quantitative trait locus influencing estrogen levels maps to a region homologous to human chromosome 20. Physiol Genomics. 2001 Mar 8;5(2):75-80.
Martin, L. J. ; Blangero, J. ; Rogers, J. ; Mahaney, M. C. ; Hixson, J. E. ; Carey, K. D. ; Morin, P. A. ; Comuzzie, A. G. / A quantitative trait locus influencing estrogen levels maps to a region homologous to human chromosome 20. In: Physiol Genomics. 2001 ; Vol. 5, No. 2. pp. 75-80.
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