A quantitative trait locus influencing activin-to-estrogen ratio in pedigreed baboons maps to a region homologous to human chromosome 19

Lisa J. Martin, John Blangero, Jeffrey Rogers, Michael C. Mahaney, James E. Hixson, K. Dee Carey, Anthony G. Comuzzie

    Research output: Contribution to journalArticlepeer-review

    6 Scopus citations

    Abstract

    Activin is a multifunctional hormone playing a major role in the regulation of reproduction and growth and development. We performed a genomewide scan using multipoint linkage analysis implemented in a general pedigree-based variance component approach to identify genes with measurable effects on variation in the activin-to-estrogen ratio in baboons. A microsatellite polymorphism, D19S714, which maps to human chromosome 19p 13.2, showed marginal evidence of linkage with a lod (log10 of the odds in favor of genetic linkage) score of 1.95 (0.014). This region contains several potential candidate genes including PKA (protein kinase, cAMP-dependent, catalytic α) and the gene pair JUN-B and JUN-D. This is the first evidence of a quantitative trait locus with a significant effect on the activin-to-estrogen ratio.

    Original languageEnglish (US)
    Pages (from-to)787-800
    Number of pages14
    JournalHuman Biology
    Volume73
    Issue number6
    DOIs
    StatePublished - 2001

    Keywords

    • Genome scan
    • Multipoint linkage
    • Papio/human homologue
    • QTL

    ASJC Scopus subject areas

    • Ecology, Evolution, Behavior and Systematics
    • Genetics
    • Genetics(clinical)

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