A quantitative trait locus influences coordinated variation in measures of ApoB-containing lipoproteins

David L. Rainwater, Michael C. Mahaney, John L. Vandeberg, Gerome Brush, Laura Almasy, John Blangero, Bennett Dyke, James E. Hixson, Shelley A. Cole, Jean W. MacCluer

    Research output: Contribution to journalArticle

    5 Scopus citations

    Abstract

    Lipoprotein phenotypes are known to be strongly intercorrelated. These intercorrelations are due to genetic and environmental effects on common metabolic pathways. The purpose of this study was to determine if we could localize genes that exert pleiotropic effects on multiple related lipoprotein traits in humans. Using data from the San Antonio Family Heart Study, we extracted principal components from a set of 12 intercorrelated lipoprotein traits that included phenotypes reflecting lipid and protein concentrations and size distributions for LDLs and HDLs. Five principal components were extracted from the data and all were significantly heritable (h2 = 0.41-0.57). When subjected to linkage analyses, only one, Component 5, returned a LOD score ≥ 3 (LOD score was 3.0 at 38 cM on chromosome 15; genome-wide P-value = 0.039). LDL median diameter (-0.529), non-HDLC (-0.422), and ApoB (-0.403) concentrations were the only traits with loadings (absolute value) >0.4, suggesting Component 5 is related to LDL size or perhaps more generally to β-lipoprotein metabolism. Surprisingly, none of the 12 original lipoprotein traits had a LOD >1 in this region of chromosome 15. These data provide evidence for a novel gene, influencing β-lipoprotein phenotypes, whose effect(s) is detected only when several lipoprotein traits are considered together.

    Original languageEnglish (US)
    Pages (from-to)379-386
    Number of pages8
    JournalAtherosclerosis
    Volume176
    Issue number2
    DOIs
    StatePublished - Oct 1 2004

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    Keywords

    • ApoB
    • Genome-wide screen
    • LDL
    • Linkage analysis
    • Lipoproteins
    • Mexican-Americans

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

    Cite this

    Rainwater, D. L., Mahaney, M. C., Vandeberg, J. L., Brush, G., Almasy, L., Blangero, J., Dyke, B., Hixson, J. E., Cole, S. A., & MacCluer, J. W. (2004). A quantitative trait locus influences coordinated variation in measures of ApoB-containing lipoproteins. Atherosclerosis, 176(2), 379-386. https://doi.org/10.1016/j.atherosclerosis.2004.06.004