A QTL for genotype by sex interaction for anthropometric measurements in Alaskan Eskimos (GOCADAN study) on chromosome 19q12-13

V. Saroja Voruganti, Vincent P. Diego, Karin Haack, Shelley A. Cole, John Blangero, Harald H.H. Göring, Sandra Laston, Charlotte R. Wenger, Sven O.E. Ebbesson, Richard R. Fabsitz, Richard B. Devereux, Barbara V. Howard, Jason G. Umans, Jean W. MacCluer, Anthony G. Comuzzie

    Research output: Contribution to journalArticle

    8 Scopus citations

    Abstract

    Variation in anthropometric measurements due to sexual dimorphism can be the result of genotype by sex interactions (G×S). The purpose of this study was to examine the sex-specific genetic architecture in anthropometric measurements in Alaskan Eskimos from the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study. Maximum likelihood-based variance components decomposition methods, implemented in SOLAR, were used for G×S analyses. Anthropometric measurements included BMI, waist circumference (WC), waist/height ratio, percent body fat (%BF), and subscapular and triceps skinfolds. Except for WC, mean values of all phenotypes were significantly different in men and women (P<0.05). All anthropometric measures were significantly heritable (P<0.001). In a preliminary analysis not allowing for G×S interaction, evidence of linkage was detected between markers D19S414 and D19S220 on chromosome 19 for WC (logarithm of odds (lod) = 3.5), %BF (lod = 1.7), BMI (lod = 2.4), waist/height ratio (lod = 2.5), subscapular (lod = 2.1), and triceps skinfolds (lod = 1.9). In subsequent analyses which allowed for G×S interaction, linkage was again found between these traits and the same two markers on chromosome 19 with significantly improved lod scores for: WC (lod = 4.5), %BF (lod = 3.8), BMI (lod = 3.5), waist/height ratio (lod = 3.2), subscapular (lod = 3.0), and triceps skinfolds (lod = 2.9). These results support the evidence of a G×S interaction in the expression of genetic effects resulting in sexual dimorphism in anthropometric phenotypes and identify the chromosome 19q12-13 region as important for adiposity-related traits in Alaskan Eskimos.

    Original languageEnglish (US)
    Pages (from-to)1840-1846
    Number of pages7
    JournalObesity
    Volume19
    Issue number9
    DOIs
    StatePublished - Sep 2011

    ASJC Scopus subject areas

    • Medicine (miscellaneous)
    • Endocrinology, Diabetes and Metabolism
    • Endocrinology
    • Nutrition and Dietetics

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  • Cite this

    Voruganti, V. S., Diego, V. P., Haack, K., Cole, S. A., Blangero, J., Göring, H. H. H., Laston, S., Wenger, C. R., Ebbesson, S. O. E., Fabsitz, R. R., Devereux, R. B., Howard, B. V., Umans, J. G., MacCluer, J. W., & Comuzzie, A. G. (2011). A QTL for genotype by sex interaction for anthropometric measurements in Alaskan Eskimos (GOCADAN study) on chromosome 19q12-13. Obesity, 19(9), 1840-1846. https://doi.org/10.1038/oby.2011.78