A prospective study of Trichomonas vaginalis and prostate cancer risk among African American men

Jay H. Fowke; Xijing Han; J. F. Alderete; Kelvin A. Moses; Lisa B. Signorello; William J. Blot

doi:10.1186/s13104-016-2033-3

A prospective study of Trichomonas vaginalis and prostate cancer risk among African American men

Jay H. Fowke, Xijing Han, J. F. Alderete, Kelvin A. Moses, Lisa B. Signorello, William J. Blot

Department of Microbiology, Immunology & Molecular Genetics

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Background: African Americans (AA) have a higher prevalence of Trichomonas vaginalis (Tv) infection and a higher prostate (PC) risk. Past studies suggest an association between Tv seropositivity and PC, and therefore we prospectively investigated this association among AA men. Results: Incident PC cases were individually matched to controls in a nested case-control study within the Southern Community Cohort Study (SCCS). Primary analysis included 296 PC cases and 497 race-matched controls. Levels of Tv antibody response were measured by ELISA in serum collected at baseline. Tv antibody response did not significantly differ between cases and controls overall or within AA participants (253 AA cases). There were no significant associations or trends between levels of Tv response and PC risk or the diagnosis of aggressive PC. Conclusion: We found no evidence of a prospective association between baseline Tv infection and PC risk in AA men. Tv infection in men may have substantial health implications in HIV transmission and reproductive outcomes, but may not impact future PC risk in AA men at high-risk for PC. Further efforts need to define past vs. present Tv infection and to separate pathophysiology from PC detection.

Original language	English (US)
Article number	224
Journal	BMC Research Notes
Volume	9
Issue number	1
DOIs	https://doi.org/10.1186/s13104-016-2033-3
State	Published - Apr 18 2016

Keywords

Prostate cancer
Race
Trichomonas vaginalis

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1186/s13104-016-2033-3

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title = "A prospective study of Trichomonas vaginalis and prostate cancer risk among African American men",

abstract = "Background: African Americans (AA) have a higher prevalence of Trichomonas vaginalis (Tv) infection and a higher prostate (PC) risk. Past studies suggest an association between Tv seropositivity and PC, and therefore we prospectively investigated this association among AA men. Results: Incident PC cases were individually matched to controls in a nested case-control study within the Southern Community Cohort Study (SCCS). Primary analysis included 296 PC cases and 497 race-matched controls. Levels of Tv antibody response were measured by ELISA in serum collected at baseline. Tv antibody response did not significantly differ between cases and controls overall or within AA participants (253 AA cases). There were no significant associations or trends between levels of Tv response and PC risk or the diagnosis of aggressive PC. Conclusion: We found no evidence of a prospective association between baseline Tv infection and PC risk in AA men. Tv infection in men may have substantial health implications in HIV transmission and reproductive outcomes, but may not impact future PC risk in AA men at high-risk for PC. Further efforts need to define past vs. present Tv infection and to separate pathophysiology from PC detection.",

keywords = "Prostate cancer, Race, Trichomonas vaginalis",

author = "Fowke, {Jay H.} and Xijing Han and Alderete, {J. F.} and Moses, {Kelvin A.} and Signorello, {Lisa B.} and Blot, {William J.}",

note = "Funding Information: This work was supported by NIH RO1CA92447. Publisher Copyright: {\textcopyright} 2016 Fowke et al.",

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AU - Han, Xijing

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AU - Signorello, Lisa B.

AU - Blot, William J.

PY - 2016/4/18

Y1 - 2016/4/18

N2 - Background: African Americans (AA) have a higher prevalence of Trichomonas vaginalis (Tv) infection and a higher prostate (PC) risk. Past studies suggest an association between Tv seropositivity and PC, and therefore we prospectively investigated this association among AA men. Results: Incident PC cases were individually matched to controls in a nested case-control study within the Southern Community Cohort Study (SCCS). Primary analysis included 296 PC cases and 497 race-matched controls. Levels of Tv antibody response were measured by ELISA in serum collected at baseline. Tv antibody response did not significantly differ between cases and controls overall or within AA participants (253 AA cases). There were no significant associations or trends between levels of Tv response and PC risk or the diagnosis of aggressive PC. Conclusion: We found no evidence of a prospective association between baseline Tv infection and PC risk in AA men. Tv infection in men may have substantial health implications in HIV transmission and reproductive outcomes, but may not impact future PC risk in AA men at high-risk for PC. Further efforts need to define past vs. present Tv infection and to separate pathophysiology from PC detection.

AB - Background: African Americans (AA) have a higher prevalence of Trichomonas vaginalis (Tv) infection and a higher prostate (PC) risk. Past studies suggest an association between Tv seropositivity and PC, and therefore we prospectively investigated this association among AA men. Results: Incident PC cases were individually matched to controls in a nested case-control study within the Southern Community Cohort Study (SCCS). Primary analysis included 296 PC cases and 497 race-matched controls. Levels of Tv antibody response were measured by ELISA in serum collected at baseline. Tv antibody response did not significantly differ between cases and controls overall or within AA participants (253 AA cases). There were no significant associations or trends between levels of Tv response and PC risk or the diagnosis of aggressive PC. Conclusion: We found no evidence of a prospective association between baseline Tv infection and PC risk in AA men. Tv infection in men may have substantial health implications in HIV transmission and reproductive outcomes, but may not impact future PC risk in AA men at high-risk for PC. Further efforts need to define past vs. present Tv infection and to separate pathophysiology from PC detection.

KW - Prostate cancer

KW - Race

KW - Trichomonas vaginalis

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A prospective study of Trichomonas vaginalis and prostate cancer risk among African American men

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