A prospective, randomized trial comparing two different intrauterine insemination regimens in controlled ovarian hyperstimulation cycles

K. M. Silverberg, J. V. Johnson, D. L. Olive, W. N. Burns, R. S. Schenken

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Objective: To compare a single periovulatory intrauterine insemination (IUI) with a regimen employing two IUIs, one before ovulation and one after ovulation, in patients undergoing controlled ovarian hyperstimulation with human menopausal gonadotropins (hMG) combined with human chorionic gonadotropin (hCG). Design: A randomized, prospective trial. Participants: Thirty-one consecutive patients undergoing 49 cycles of controlled ovarian hyperstimulation/IUI were studied in a tertiary care setting. Main Outcome Measures: Ovulation was determined sonographically. The establishment of a clinical pregnancy was defined by either ultrasonographic verification of cardiac activity within an intrauterine fetus, or histologic confirmation of trophoblast in a surgical specimen. Results: Clinical pregnancies developed in 2 of 23 cycles in the single insemination group, compared with 12 of the 23 cycles in the double insemination group. Cycle fecundity was significantly higher for group II (0.522) than for group I (0.087) patients (P = 0.003). Conclusion: In hMG/hCG cycles, two IUIs timed as described above are superior to one periovulatory insemination.

Original languageEnglish (US)
Pages (from-to)357-361
Number of pages5
JournalFertility and sterility
Volume57
Issue number2
StatePublished - Jan 1 1992

Keywords

  • Intrauterine insemination
  • fertility
  • gonadotropins
  • human menotropins
  • ovulation induction
  • prospective study

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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