Abstract
Objective: To compare a single periovulatory intrauterine insemination (IUI) with a regimen employing two IUIs, one before ovulation and one after ovulation, in patients undergoing controlled ovarian hyperstimulation with human menopausal gonadotropins (hMG) combined with human chorionic gonadotropin (hCG). Design: A randomized, prospective trial. Participants: Thirty-one consecutive patients undergoing 49 cycles of controlled ovarian hyperstimulation/IUI were studied in a tertiary care setting. Main Outcome Measures: Ovulation was determined sonographically. The establishment of a clinical pregnancy was defined by either ultrasonographic verification of cardiac activity within an intrauterine fetus, or histologic confirmation of trophoblast in a surgical specimen. Results: Clinical pregnancies developed in 2 of 23 cycles in the single insemination group, compared with 12 of the 23 cycles in the double insemination group. Cycle fecundity was significantly higher for group II (0.522) than for group I (0.087) patients (P = 0.003). Conclusion: In hMG/hCG cycles, two IUIs timed as described above are superior to one periovulatory insemination.
Original language | English (US) |
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Pages (from-to) | 357-361 |
Number of pages | 5 |
Journal | Fertility and sterility |
Volume | 57 |
Issue number | 2 |
DOIs | |
State | Published - 1992 |
Keywords
- Intrauterine insemination
- fertility
- gonadotropins
- human menotropins
- ovulation induction
- prospective study
ASJC Scopus subject areas
- Obstetrics and Gynecology
- Reproductive Medicine