A priori collaboration in population imaging

The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium

Hieab H.H. Adams, Saima Hilal, Petra Schwingenschuh, Katharina Wittfeld, Sven J. van der Lee, Charles DeCarli, Meike W. Vernooij, Petra Katschnig-Winter, Mohamad Habes, Christopher Chen, Sudha Seshadri, Cornelia M. van Duijn, M. Kamran Ikram, Hans J. Grabe, Reinhold Schmidt, M. Arfan Ikram

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Introduction: Virchow-Robin spaces (VRS), or perivascular spaces, are compartments of interstitial fluid enclosing cerebral blood vessels and are potential imaging markers of various underlying brain pathologies. Despite a growing interest in the study of enlarged VRS, the heterogeneity in rating and quantification methods combined with small sample sizes have so far hampered advancement in the field. Methods: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement (UNIVRSE) consortium was established with primary aims to harmonize rating and analysis (www.uconsortium.org). The UNIVRSE consortium brings together 13 (sub)cohorts from five countries, totaling 16,000 subjects and over 25,000 scans. Eight different magnetic resonance imaging protocols were used in the consortium. Results: VRS rating was harmonized using a validated protocol that was developed by the two founding members, with high reliability independent of scanner type, rater experience, or concomitant brain pathology. Initial analyses revealed risk factors for enlarged VRS including increased age, sex, high blood pressure, brain infarcts, and white matter lesions, but this varied by brain region. Discussion: Early collaborative efforts between cohort studies with respect to data harmonization and joint analyses can advance the field of population (neuro)imaging. The UNIVRSE consortium will focus efforts on other potential correlates of enlarged VRS, including genetics, cognition, stroke, and dementia.

Original languageEnglish (US)
Pages (from-to)513-520
Number of pages8
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume1
Issue number4
DOIs
StatePublished - Dec 1 2015
Externally publishedYes

Fingerprint

Songbirds
Population
Brain
Pathology
Extracellular Fluid
Sample Size
Cognition
Blood Vessels
Dementia
Cohort Studies
Joints
Stroke
Magnetic Resonance Imaging
Hypertension

Keywords

  • Cerebrovascular disease
  • Dementia
  • Magnetic resonance imaging
  • Population based
  • Population imaging
  • Risk factors
  • Stroke
  • Virchow-Robin spaces

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

A priori collaboration in population imaging : The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium. / Adams, Hieab H.H.; Hilal, Saima; Schwingenschuh, Petra; Wittfeld, Katharina; van der Lee, Sven J.; DeCarli, Charles; Vernooij, Meike W.; Katschnig-Winter, Petra; Habes, Mohamad; Chen, Christopher; Seshadri, Sudha; van Duijn, Cornelia M.; Ikram, M. Kamran; Grabe, Hans J.; Schmidt, Reinhold; Ikram, M. Arfan.

In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 1, No. 4, 01.12.2015, p. 513-520.

Research output: Contribution to journalArticle

Adams, HHH, Hilal, S, Schwingenschuh, P, Wittfeld, K, van der Lee, SJ, DeCarli, C, Vernooij, MW, Katschnig-Winter, P, Habes, M, Chen, C, Seshadri, S, van Duijn, CM, Ikram, MK, Grabe, HJ, Schmidt, R & Ikram, MA 2015, 'A priori collaboration in population imaging: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 1, no. 4, pp. 513-520. https://doi.org/10.1016/j.dadm.2015.10.004
Adams, Hieab H.H. ; Hilal, Saima ; Schwingenschuh, Petra ; Wittfeld, Katharina ; van der Lee, Sven J. ; DeCarli, Charles ; Vernooij, Meike W. ; Katschnig-Winter, Petra ; Habes, Mohamad ; Chen, Christopher ; Seshadri, Sudha ; van Duijn, Cornelia M. ; Ikram, M. Kamran ; Grabe, Hans J. ; Schmidt, Reinhold ; Ikram, M. Arfan. / A priori collaboration in population imaging : The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium. In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 2015 ; Vol. 1, No. 4. pp. 513-520.
@article{65bd6b0b804549eaa1c869ddb483ccff,
title = "A priori collaboration in population imaging: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium",
abstract = "Introduction: Virchow-Robin spaces (VRS), or perivascular spaces, are compartments of interstitial fluid enclosing cerebral blood vessels and are potential imaging markers of various underlying brain pathologies. Despite a growing interest in the study of enlarged VRS, the heterogeneity in rating and quantification methods combined with small sample sizes have so far hampered advancement in the field. Methods: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement (UNIVRSE) consortium was established with primary aims to harmonize rating and analysis (www.uconsortium.org). The UNIVRSE consortium brings together 13 (sub)cohorts from five countries, totaling 16,000 subjects and over 25,000 scans. Eight different magnetic resonance imaging protocols were used in the consortium. Results: VRS rating was harmonized using a validated protocol that was developed by the two founding members, with high reliability independent of scanner type, rater experience, or concomitant brain pathology. Initial analyses revealed risk factors for enlarged VRS including increased age, sex, high blood pressure, brain infarcts, and white matter lesions, but this varied by brain region. Discussion: Early collaborative efforts between cohort studies with respect to data harmonization and joint analyses can advance the field of population (neuro)imaging. The UNIVRSE consortium will focus efforts on other potential correlates of enlarged VRS, including genetics, cognition, stroke, and dementia.",
keywords = "Cerebrovascular disease, Dementia, Magnetic resonance imaging, Population based, Population imaging, Risk factors, Stroke, Virchow-Robin spaces",
author = "Adams, {Hieab H.H.} and Saima Hilal and Petra Schwingenschuh and Katharina Wittfeld and {van der Lee}, {Sven J.} and Charles DeCarli and Vernooij, {Meike W.} and Petra Katschnig-Winter and Mohamad Habes and Christopher Chen and Sudha Seshadri and {van Duijn}, {Cornelia M.} and Ikram, {M. Kamran} and Grabe, {Hans J.} and Reinhold Schmidt and Ikram, {M. Arfan}",
year = "2015",
month = "12",
day = "1",
doi = "10.1016/j.dadm.2015.10.004",
language = "English (US)",
volume = "1",
pages = "513--520",
journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",
issn = "2352-8729",
publisher = "Elsevier BV",
number = "4",

}

TY - JOUR

T1 - A priori collaboration in population imaging

T2 - The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium

AU - Adams, Hieab H.H.

AU - Hilal, Saima

AU - Schwingenschuh, Petra

AU - Wittfeld, Katharina

AU - van der Lee, Sven J.

AU - DeCarli, Charles

AU - Vernooij, Meike W.

AU - Katschnig-Winter, Petra

AU - Habes, Mohamad

AU - Chen, Christopher

AU - Seshadri, Sudha

AU - van Duijn, Cornelia M.

AU - Ikram, M. Kamran

AU - Grabe, Hans J.

AU - Schmidt, Reinhold

AU - Ikram, M. Arfan

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Introduction: Virchow-Robin spaces (VRS), or perivascular spaces, are compartments of interstitial fluid enclosing cerebral blood vessels and are potential imaging markers of various underlying brain pathologies. Despite a growing interest in the study of enlarged VRS, the heterogeneity in rating and quantification methods combined with small sample sizes have so far hampered advancement in the field. Methods: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement (UNIVRSE) consortium was established with primary aims to harmonize rating and analysis (www.uconsortium.org). The UNIVRSE consortium brings together 13 (sub)cohorts from five countries, totaling 16,000 subjects and over 25,000 scans. Eight different magnetic resonance imaging protocols were used in the consortium. Results: VRS rating was harmonized using a validated protocol that was developed by the two founding members, with high reliability independent of scanner type, rater experience, or concomitant brain pathology. Initial analyses revealed risk factors for enlarged VRS including increased age, sex, high blood pressure, brain infarcts, and white matter lesions, but this varied by brain region. Discussion: Early collaborative efforts between cohort studies with respect to data harmonization and joint analyses can advance the field of population (neuro)imaging. The UNIVRSE consortium will focus efforts on other potential correlates of enlarged VRS, including genetics, cognition, stroke, and dementia.

AB - Introduction: Virchow-Robin spaces (VRS), or perivascular spaces, are compartments of interstitial fluid enclosing cerebral blood vessels and are potential imaging markers of various underlying brain pathologies. Despite a growing interest in the study of enlarged VRS, the heterogeneity in rating and quantification methods combined with small sample sizes have so far hampered advancement in the field. Methods: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement (UNIVRSE) consortium was established with primary aims to harmonize rating and analysis (www.uconsortium.org). The UNIVRSE consortium brings together 13 (sub)cohorts from five countries, totaling 16,000 subjects and over 25,000 scans. Eight different magnetic resonance imaging protocols were used in the consortium. Results: VRS rating was harmonized using a validated protocol that was developed by the two founding members, with high reliability independent of scanner type, rater experience, or concomitant brain pathology. Initial analyses revealed risk factors for enlarged VRS including increased age, sex, high blood pressure, brain infarcts, and white matter lesions, but this varied by brain region. Discussion: Early collaborative efforts between cohort studies with respect to data harmonization and joint analyses can advance the field of population (neuro)imaging. The UNIVRSE consortium will focus efforts on other potential correlates of enlarged VRS, including genetics, cognition, stroke, and dementia.

KW - Cerebrovascular disease

KW - Dementia

KW - Magnetic resonance imaging

KW - Population based

KW - Population imaging

KW - Risk factors

KW - Stroke

KW - Virchow-Robin spaces

UR - http://www.scopus.com/inward/record.url?scp=84949761526&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84949761526&partnerID=8YFLogxK

U2 - 10.1016/j.dadm.2015.10.004

DO - 10.1016/j.dadm.2015.10.004

M3 - Article

VL - 1

SP - 513

EP - 520

JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

SN - 2352-8729

IS - 4

ER -