A Previously Unrecognized Monocytic Component of Pheochromocytoma and Paraganglioma

Nada A. Farhat, James F. Powers, Annette Shepard-Barry, Patricia Dahia, Karel Pacak, Arthur S. Tischler

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

We describe a consistently present, previously unrecognized, population of monocytes in pheochromocytomas and paragangliomas. Although sustentacular cells are generally recognized as a common component of these tumors, differential immunohistochemical staining for CD163 and S100 shows that monocytes can in fact be more numerous. These cells frequently resemble sustentacular cells topographically and cytologically, possibly explaining why they have not been previously noticed. They contribute to the tumor proteome and may have implications for tumor biology. No correlations were identifiable between the presence of these cells and any clinical characteristics of the tumors in the present study. A possible association with genotype is suggested by immunoblot showing high expression of CD163 protein in tumors with succinate dehydrogenase mutations.

Original languageEnglish (US)
Pages (from-to)90-95
Number of pages6
JournalEndocrine Pathology
Volume30
Issue number2
DOIs
StatePublished - Jun 15 2019

Keywords

  • Immunohistochemistry
  • Macrophage
  • Monocyte
  • Paraganglioma
  • Pheochromocytoma
  • Sustentacular cell

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Farhat, N. A., Powers, J. F., Shepard-Barry, A., Dahia, P., Pacak, K., & Tischler, A. S. (2019). A Previously Unrecognized Monocytic Component of Pheochromocytoma and Paraganglioma. Endocrine Pathology, 30(2), 90-95. https://doi.org/10.1007/s12022-019-9575-6