A preliminary report on the feeding of cynomolgus monkeys (Macaca fascicularis) with a high-sugar high-fat diet for 33weeks

James N. Mubiru, Magdalena Garcia-Forey, Paul B. Higgins, Peggah Hemmat, Nicole E. Cavazos, Edward J. Dick, Michael A. Owston, Cassondra A. Bauer, Robert E. Shade, Anthony G. Comuzzie, Jeffrey Rogers

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    Abstract

    Background The metabolic syndrome is common in populations exposed to a typical Western diet. There is a lack of an animal model that mimics this condition. Methods We fed 15 cynomolgus monkeys ad libitum a high-sugar high-fat (HSHF) diet for 33weeks. Body weight, body composition, serum lipids, and insulin were measured at baseline and at 33weeks. Results The animals tolerated the HSHF diet very well. In the intervention group, total serum cholesterol and low-density lipoprotein cholesterol were 3- and 5-fold higher, respectively, at 33weeks as compared with their baseline levels. Serum high-density lipoprotein cholesterol and triglycerides were not significantly affected. Dual-energy X-ray absorptiometry (DXA) analysis of the intervention group indicated that the trunk fat mass increased by 187% during this period. Conclusions Cynomolgus monkeys should be a useful model for investigating the interactions of diet and other factors such as genetics in the development of the metabolic syndrome.

    Original languageEnglish (US)
    Pages (from-to)335-341
    Number of pages7
    JournalJournal of medical primatology
    Volume40
    Issue number5
    DOIs
    StatePublished - Oct 1 2011

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    Keywords

    • Dual X-ray absorptiometry
    • Insulin
    • Low-density lipoprotein cholesterol
    • Triglyceride

    ASJC Scopus subject areas

    • Animal Science and Zoology
    • veterinary(all)

    Cite this

    Mubiru, J. N., Garcia-Forey, M., Higgins, P. B., Hemmat, P., Cavazos, N. E., Dick, E. J., Owston, M. A., Bauer, C. A., Shade, R. E., Comuzzie, A. G., & Rogers, J. (2011). A preliminary report on the feeding of cynomolgus monkeys (Macaca fascicularis) with a high-sugar high-fat diet for 33weeks. Journal of medical primatology, 40(5), 335-341. https://doi.org/10.1111/j.1600-0684.2011.00495.x