A preliminary clinical study of ct1341-a steroid anaesthetic agent

Donald Campbell, Alex C. Forrester, Donald C. Miller, I. Hutton, J. A. Kennedy, T. D.V. Lawrie, A. R. Lorimer, D. Mccall

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

Summary: The effects of a new steroid anaesthetic agent (CT1341) were studied in twenty volunteers divided into three groups. In group I, serial measurements were made of heart rate, blood pressure and respiratory rate. In group II, detailed haemodynamic studies were made in patients undergoing diagnostic cardiovascular investigations. These studies included measurement of cardiac output, stroke volume and arterial blood gases. In group III, time from induction to "true recovery" was measured following a single intravenous injection of the drug. This agent produced a stable anaesthetic state in all cases. Anaesthesia was characterized by a rise in respiratory rate and pulse rate with a slight fall in systolic and diastolic blood pressure. A significant fall in Pao2 occurred in those patients breathing air. The mean recovery time in six patients was 24.3 min. CT1341 produced safe and stable anaesthesia in all twenty cases and is worthy of further clinical trial.

Original languageEnglish (US)
Pages (from-to)14-24
Number of pages11
JournalBritish Journal of Anaesthesia
Volume43
Issue number1
DOIs
StatePublished - Jan 1971

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Fingerprint Dive into the research topics of 'A preliminary clinical study of ct1341-a steroid anaesthetic agent'. Together they form a unique fingerprint.

Cite this