A potential role for immune activation in hemodialysis hypotension

M. Tomita, D. Malhotra, S. Dheenan, J. I. Shapiro, W. L. Henrich, T. J. Santoro

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The necessary exposure of blood to biomembranes during hemodialysis has been viewed by many as an immunogenic challenge leading to an acute phase response. In this study we examined the relationship between hemodialysis-induced immune activation and intradialytic hypotension, using the acute phase reactant serum C-reactive protein (CRP) as a surrogate for immunogenic activation. The maximum percent change in mean arterial pressure (MAP) was found to correlate significantly with CRP (r=0.67, p < 0.05) in nine consecutive patients with a history of symptomatic hypotension during hemodialysis. In contrast, no correlation was found between CRP and maximum percent change in MAP in eight consecutive hemodialysis patients without intradialytic hypotension. Since interleukin-6 (IL-6) is a major regulator of CRP, the relationship between these two proteins was examined. Plasma IL-6 levels were found to correlate both with CRP (r=0.67, p < 0.05) and with mean maximum percent change in MAP (r=0.70, p < 0.05) in hemodialysis patients with a prior history of hypotension. IL-6 levels did not correlate with CRP or blood pressure in the hemodynamically stable patients. The results suggest that immune activation working through IL-6, CRP and other cytokines may play a role in the pathogenesis of hemodialysis hypotension in some patients.

Original languageEnglish (US)
Pages (from-to)637-649
Number of pages13
JournalRenal Failure
Volume23
Issue number5
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Nephrology

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