A positron-probe system for arterial input function quantification for positron emission tomography in humans

Kihak Lee; Peter T. Fox; Jack L. Lancaster; Paul A. Jerabek

doi:10.1063/1.2936880

A positron-probe system for arterial input function quantification for positron emission tomography in humans

Kihak Lee, Peter T. Fox, Jack L. Lancaster, Paul A. Jerabek

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We developed an intra-arterial positron-probe (Β+ -probe) system to measure the arterial time-activity concentration in humans for quantitative compartmental modeling of positron emission tomography studies. Performance was characterized in vitro, by using a uniform phantom to calculate dead time, linearity, and absolute detector sensitivity. In vitro evaluations in a uniform phantom showed a system dead time of 2.5 μs, linear regression between measured and true count rates with R2 =0.999, and detector sensitivity of 6.9-7.0 countss kBq-1 ml. These met or exceeded values of previously reported systems.

Original language	English (US)
Article number	064301
Journal	Review of Scientific Instruments
Volume	79
Issue number	6
DOIs	https://doi.org/10.1063/1.2936880
State	Published - 2008
Externally published	Yes

ASJC Scopus subject areas

Instrumentation

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10.1063/1.2936880

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title = "A positron-probe system for arterial input function quantification for positron emission tomography in humans",

abstract = "We developed an intra-arterial positron-probe (Β+ -probe) system to measure the arterial time-activity concentration in humans for quantitative compartmental modeling of positron emission tomography studies. Performance was characterized in vitro, by using a uniform phantom to calculate dead time, linearity, and absolute detector sensitivity. In vitro evaluations in a uniform phantom showed a system dead time of 2.5 μs, linear regression between measured and true count rates with R2 =0.999, and detector sensitivity of 6.9-7.0 countss kBq-1 ml. These met or exceeded values of previously reported systems.",

author = "Kihak Lee and Fox, {Peter T.} and Lancaster, {Jack L.} and Jerabek, {Paul A.}",

note = "Funding Information: We thank Mr. John Roby for helpful advice on constructing the -probe system. We thank Dr. Robert W. Laird for help obtaining energy spectra. We thank Morgan D. Stratton and Amanda M. Sullivan for technical assistance. This work was supported by Grant No. R21 NS050486 (PI: Peter T. Fox) from the NIH/NINDS.",

year = "2008",

doi = "10.1063/1.2936880",

language = "English (US)",

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journal = "Review of Scientific Instruments",

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T1 - A positron-probe system for arterial input function quantification for positron emission tomography in humans

AU - Lee, Kihak

AU - Fox, Peter T.

AU - Lancaster, Jack L.

AU - Jerabek, Paul A.

N1 - Funding Information: We thank Mr. John Roby for helpful advice on constructing the -probe system. We thank Dr. Robert W. Laird for help obtaining energy spectra. We thank Morgan D. Stratton and Amanda M. Sullivan for technical assistance. This work was supported by Grant No. R21 NS050486 (PI: Peter T. Fox) from the NIH/NINDS.

PY - 2008

Y1 - 2008

N2 - We developed an intra-arterial positron-probe (Β+ -probe) system to measure the arterial time-activity concentration in humans for quantitative compartmental modeling of positron emission tomography studies. Performance was characterized in vitro, by using a uniform phantom to calculate dead time, linearity, and absolute detector sensitivity. In vitro evaluations in a uniform phantom showed a system dead time of 2.5 μs, linear regression between measured and true count rates with R2 =0.999, and detector sensitivity of 6.9-7.0 countss kBq-1 ml. These met or exceeded values of previously reported systems.

AB - We developed an intra-arterial positron-probe (Β+ -probe) system to measure the arterial time-activity concentration in humans for quantitative compartmental modeling of positron emission tomography studies. Performance was characterized in vitro, by using a uniform phantom to calculate dead time, linearity, and absolute detector sensitivity. In vitro evaluations in a uniform phantom showed a system dead time of 2.5 μs, linear regression between measured and true count rates with R2 =0.999, and detector sensitivity of 6.9-7.0 countss kBq-1 ml. These met or exceeded values of previously reported systems.

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A positron-probe system for arterial input function quantification for positron emission tomography in humans

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