We developed an intra-arterial positron-probe (Β+ -probe) system to measure the arterial time-activity concentration in humans for quantitative compartmental modeling of positron emission tomography studies. Performance was characterized in vitro, by using a uniform phantom to calculate dead time, linearity, and absolute detector sensitivity. In vitro evaluations in a uniform phantom showed a system dead time of 2.5 μs, linear regression between measured and true count rates with R2 =0.999, and detector sensitivity of 6.9-7.0 countss kBq-1 ml. These met or exceeded values of previously reported systems.
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