A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis

Luis Miguel Gómez, Juan Manuel Anaya, José Ramón Vilchez, Jose Cadena, Rosa Hinojosa, Luciano Vélez, Miguel Angel Lopez-Nevot, Javier Martín

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

iNOS or NOS2 is a molecule that plays a key role in the immunological control of a broad spectrum of infectious agents. Investigation is hampered by difficulty in estimating in vivo production of nitric oxide (NO), but genetic studies provide a potential means of examining the relation between NO production and disease outcome. To better characterize the host genetic factors determining the susceptibility to TB, we evaluated the influence of two polymorphisms in the NOS2A gene on the risk of developing pulmonary TB in a Northwestern Colombian population, which is a moderately-high endemic area. One hundred and fourteen patients with TB and negative for human immunodeficiency virus, plus 304 healthy controls were examined for NOS2A CCTTT and TAAA polymorphisms. A total of 160 healthy controls mentioned before, underwent tuberculin skin test (TST). Analysis disclosed significant differences between patients and controls with NOS2A CCTTT polymorphism (P=0.0001, Pc=0.001, OR=0.4, and 95%CI=0.3-0.7) independent of TST status. When the NOS2A alleles were stratified into short (8-11) and long (12-16) repeats, significant differences with short repeats were observed between TB patients and all controls (P=0.005, OR=0.63, 95%CI=0.46-0.86). No individual association with NOS2A TAAA was detected. These results indicate that a polymorphism in the NOS2A gene influences the susceptibility to TB and suggest a role for NOS2A in the pathogenesis of mycobacterial infection.

Original languageEnglish (US)
Pages (from-to)288-294
Number of pages7
JournalTuberculosis
Volume87
Issue number4
DOIs
StatePublished - Jul 1 2007
Externally publishedYes

Keywords

  • Genetics
  • Nitric oxide synthases
  • Tuberculosis

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

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  • Cite this

    Miguel Gómez, L., Anaya, J. M., Ramón Vilchez, J., Cadena, J., Hinojosa, R., Vélez, L., Angel Lopez-Nevot, M., & Martín, J. (2007). A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis. Tuberculosis, 87(4), 288-294. https://doi.org/10.1016/j.tube.2007.03.002