A polymorphism in the GALNT2 gene and ovarian cancer risk in four population based case-control studies

Kathryn L. Terry; Allison F. Vitonis; Dena Hernandez; Galina Lurie; Honglin Song; Susan J. Ramus; Linda Titus-Ernstoff; Michael E. Carney; Lynne R. Wilkens; Aleksandra Gentry-Maharaj; Usha Menon; Simon A. Gayther; Paul D. Pharaoh; Marc T. Goodman; Daniel W. Cramer; Michael J. Birrer

A polymorphism in the GALNT2 gene and ovarian cancer risk in four population based case-control studies

Kathryn L. Terry, Allison F. Vitonis, Dena Hernandez, Galina Lurie, Honglin Song, Susan J. Ramus, Linda Titus-Ernstoff, Michael E. Carney, Lynne R. Wilkens, Aleksandra Gentry-Maharaj, Usha Menon, Simon A. Gayther, Paul D. Pharaoh, Marc T. Goodman, Daniel W. Cramer, Michael J. Birrer

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Recent epidemiologic evidence supports a role for MUC1 in ovarian carcinogenesis; therefore, we hypothesized that common genetic variation in the genes responsible for glycosylation of MUC1 may influence ovarian cancer risk. In a genome-wide association study of ovarian cancer, we observed an association between a non-synonymous SNP (rs2271077) in the UDP-N-acetyl-alpha-d-galactosamine: polypeptide N-acetylgalactosainyltransferase 2 (GALNT2) gene and ovarian cancer risk (p=0.005). We sought to validate the association in four population based ovarian cancer case-control studies collaborating through the Ovarian Cancer Association Consortium. Although rs2271077 was associated with a significantly increased risk (Odds Ratio (OR) = 1.37, 95% Confidence Interval (CI) =1.06-1.77) in one study with 961 cases and 922 controls, we observed no association in the remaining three studies including 1452 cases and 1954 controls (OR=0.83, 95% CI= 0.66-1.04). Therefore, there appears to be no strong evidence of association between GALNT2 SNP rs2271077 and ovarian cancer risk.

Original language	English (US)
Pages (from-to)	272-277
Number of pages	6
Journal	International Journal of Molecular Epidemiology and Genetics
Volume	1
Issue number	4
State	Published - 2010
Externally published	Yes

Keywords

MUC1
Ovarian cancer
Polymorphism

ASJC Scopus subject areas

Epidemiology
Genetics
Genetics(clinical)

Cite this

Terry, K. L., Vitonis, A. F., Hernandez, D., Lurie, G., Song, H., Ramus, S. J., Titus-Ernstoff, L., Carney, M. E., Wilkens, L. R., Gentry-Maharaj, A., Menon, U., Gayther, S. A., Pharaoh, P. D., Goodman, M. T., Cramer, D. W., & Birrer, M. J. (2010). A polymorphism in the GALNT2 gene and ovarian cancer risk in four population based case-control studies. International Journal of Molecular Epidemiology and Genetics, 1(4), 272-277.

Terry, KL, Vitonis, AF, Hernandez, D, Lurie, G, Song, H, Ramus, SJ, Titus-Ernstoff, L, Carney, ME, Wilkens, LR, Gentry-Maharaj, A, Menon, U, Gayther, SA, Pharaoh, PD, Goodman, MT, Cramer, DW & Birrer, MJ 2010, 'A polymorphism in the GALNT2 gene and ovarian cancer risk in four population based case-control studies', International Journal of Molecular Epidemiology and Genetics, vol. 1, no. 4, pp. 272-277.

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title = "A polymorphism in the GALNT2 gene and ovarian cancer risk in four population based case-control studies",

abstract = "Recent epidemiologic evidence supports a role for MUC1 in ovarian carcinogenesis; therefore, we hypothesized that common genetic variation in the genes responsible for glycosylation of MUC1 may influence ovarian cancer risk. In a genome-wide association study of ovarian cancer, we observed an association between a non-synonymous SNP (rs2271077) in the UDP-N-acetyl-alpha-d-galactosamine: polypeptide N-acetylgalactosainyltransferase 2 (GALNT2) gene and ovarian cancer risk (p=0.005). We sought to validate the association in four population based ovarian cancer case-control studies collaborating through the Ovarian Cancer Association Consortium. Although rs2271077 was associated with a significantly increased risk (Odds Ratio (OR) = 1.37, 95% Confidence Interval (CI) =1.06-1.77) in one study with 961 cases and 922 controls, we observed no association in the remaining three studies including 1452 cases and 1954 controls (OR=0.83, 95% CI= 0.66-1.04). Therefore, there appears to be no strong evidence of association between GALNT2 SNP rs2271077 and ovarian cancer risk.",

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author = "Terry, {Kathryn L.} and Vitonis, {Allison F.} and Dena Hernandez and Galina Lurie and Honglin Song and Ramus, {Susan J.} and Linda Titus-Ernstoff and Carney, {Michael E.} and Wilkens, {Lynne R.} and Aleksandra Gentry-Maharaj and Usha Menon and Gayther, {Simon A.} and Pharaoh, {Paul D.} and Goodman, {Marc T.} and Cramer, {Daniel W.} and Birrer, {Michael J.}",

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AU - Terry, Kathryn L.

AU - Vitonis, Allison F.

AU - Hernandez, Dena

AU - Lurie, Galina

AU - Song, Honglin

AU - Ramus, Susan J.

AU - Titus-Ernstoff, Linda

AU - Carney, Michael E.

AU - Wilkens, Lynne R.

AU - Gentry-Maharaj, Aleksandra

AU - Menon, Usha

AU - Gayther, Simon A.

AU - Pharaoh, Paul D.

AU - Goodman, Marc T.

AU - Cramer, Daniel W.

AU - Birrer, Michael J.

PY - 2010

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N2 - Recent epidemiologic evidence supports a role for MUC1 in ovarian carcinogenesis; therefore, we hypothesized that common genetic variation in the genes responsible for glycosylation of MUC1 may influence ovarian cancer risk. In a genome-wide association study of ovarian cancer, we observed an association between a non-synonymous SNP (rs2271077) in the UDP-N-acetyl-alpha-d-galactosamine: polypeptide N-acetylgalactosainyltransferase 2 (GALNT2) gene and ovarian cancer risk (p=0.005). We sought to validate the association in four population based ovarian cancer case-control studies collaborating through the Ovarian Cancer Association Consortium. Although rs2271077 was associated with a significantly increased risk (Odds Ratio (OR) = 1.37, 95% Confidence Interval (CI) =1.06-1.77) in one study with 961 cases and 922 controls, we observed no association in the remaining three studies including 1452 cases and 1954 controls (OR=0.83, 95% CI= 0.66-1.04). Therefore, there appears to be no strong evidence of association between GALNT2 SNP rs2271077 and ovarian cancer risk.

AB - Recent epidemiologic evidence supports a role for MUC1 in ovarian carcinogenesis; therefore, we hypothesized that common genetic variation in the genes responsible for glycosylation of MUC1 may influence ovarian cancer risk. In a genome-wide association study of ovarian cancer, we observed an association between a non-synonymous SNP (rs2271077) in the UDP-N-acetyl-alpha-d-galactosamine: polypeptide N-acetylgalactosainyltransferase 2 (GALNT2) gene and ovarian cancer risk (p=0.005). We sought to validate the association in four population based ovarian cancer case-control studies collaborating through the Ovarian Cancer Association Consortium. Although rs2271077 was associated with a significantly increased risk (Odds Ratio (OR) = 1.37, 95% Confidence Interval (CI) =1.06-1.77) in one study with 961 cases and 922 controls, we observed no association in the remaining three studies including 1452 cases and 1954 controls (OR=0.83, 95% CI= 0.66-1.04). Therefore, there appears to be no strong evidence of association between GALNT2 SNP rs2271077 and ovarian cancer risk.

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KW - Ovarian cancer

KW - Polymorphism

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A polymorphism in the GALNT2 gene and ovarian cancer risk in four population based case-control studies

Abstract

Keywords

ASJC Scopus subject areas

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