A polymorphic DNA marker genetically linked to Huntington's disease

James F. Gusella, Nancy S. Wexler, P. Michael Conneally, Susan L. Naylor, Mary Anne Anderson, Rudolph E. Tanzi, Paul C. Watkins, Kathleen Ottina, Margaret R. Wallace, Alan Y. Sakaguchi, Anne B. Young, Ira Shoulson, Ernesto Bonilla, Joseph B. Martin

Research output: Contribution to journalArticle

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Abstract

Family studies show that the Huntington's disease gene is linked to a polymorphic DNA marker that maps to human chromosome 4. The chromosomal localization of the Huntington's disease gene is the first step in using recombinant DNA technology to identify the primary genetic defect in this disorder.

Original languageEnglish (US)
Pages (from-to)234-238
Number of pages5
JournalNature
Volume306
Issue number5940
DOIs
StatePublished - 1983
Externally publishedYes

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    Gusella, J. F., Wexler, N. S., Conneally, P. M., Naylor, S. L., Anderson, M. A., Tanzi, R. E., Watkins, P. C., Ottina, K., Wallace, M. R., Sakaguchi, A. Y., Young, A. B., Shoulson, I., Bonilla, E., & Martin, J. B. (1983). A polymorphic DNA marker genetically linked to Huntington's disease. Nature, 306(5940), 234-238. https://doi.org/10.1038/306234a0