Abstract
Forty-two patients with progressive solid tumors and brain tumors were entered in this Phase I study of the glutamine antagonist acivicin given intravenously over thirty minutes daily for five days. The major toxicities encountered were myelosuppression and central nervous system toxicity (nightmares and somnolence). The maximum tolerated dosage on this schedule was 26 mg/M2 daily for five days. Six patients including three patients with brain tumor had stable disease.
Original language | English (US) |
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Pages (from-to) | 211-215 |
Number of pages | 5 |
Journal | Investigational New Drugs |
Volume | 13 |
Issue number | 3 |
DOIs | |
State | Published - Sep 1995 |
Keywords
- Phase I study
- brain tumor
- glutamine
- glutathione
ASJC Scopus subject areas
- Oncology
- Pharmacology
- Pharmacology (medical)