A Phase I study of acivicin in refractory pediatric solid tumors - A Pediatric Oncology Group study

Sylvain Baruchel; Mark Bernstein; V. Michael Whitehead; Susan Devine; Beverly Bell; Ronald Dubowy; Holcombe Grier; Cynthia Kretschmar; Anne Marie Langevin; Teresa Vietti

doi:10.1007/BF00873802

A Phase I study of acivicin in refractory pediatric solid tumors - A Pediatric Oncology Group study

Sylvain Baruchel, Mark Bernstein, V. Michael Whitehead, Susan Devine, Beverly Bell, Ronald Dubowy, Holcombe Grier, Cynthia Kretschmar, Anne Marie Langevin, Teresa Vietti

Department of Pediatrics

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Forty-two patients with progressive solid tumors and brain tumors were entered in this Phase I study of the glutamine antagonist acivicin given intravenously over thirty minutes daily for five days. The major toxicities encountered were myelosuppression and central nervous system toxicity (nightmares and somnolence). The maximum tolerated dosage on this schedule was 26 mg/M² daily for five days. Six patients including three patients with brain tumor had stable disease.

Original language	English (US)
Pages (from-to)	211-215
Number of pages	5
Journal	Investigational New Drugs
Volume	13
Issue number	3
DOIs	https://doi.org/10.1007/BF00873802
State	Published - Sep 1995

Keywords

Phase I study
brain tumor
glutamine
glutathione

ASJC Scopus subject areas

Oncology
Pharmacology
Pharmacology (medical)

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10.1007/BF00873802

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title = "A Phase I study of acivicin in refractory pediatric solid tumors - A Pediatric Oncology Group study",

abstract = "Forty-two patients with progressive solid tumors and brain tumors were entered in this Phase I study of the glutamine antagonist acivicin given intravenously over thirty minutes daily for five days. The major toxicities encountered were myelosuppression and central nervous system toxicity (nightmares and somnolence). The maximum tolerated dosage on this schedule was 26 mg/M2 daily for five days. Six patients including three patients with brain tumor had stable disease.",

keywords = "Phase I study, brain tumor, glutamine, glutathione",

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AU - Baruchel, Sylvain

AU - Bernstein, Mark

AU - Whitehead, V. Michael

AU - Devine, Susan

AU - Bell, Beverly

AU - Dubowy, Ronald

AU - Grier, Holcombe

AU - Kretschmar, Cynthia

AU - Langevin, Anne Marie

AU - Vietti, Teresa

PY - 1995/9

Y1 - 1995/9

N2 - Forty-two patients with progressive solid tumors and brain tumors were entered in this Phase I study of the glutamine antagonist acivicin given intravenously over thirty minutes daily for five days. The major toxicities encountered were myelosuppression and central nervous system toxicity (nightmares and somnolence). The maximum tolerated dosage on this schedule was 26 mg/M2 daily for five days. Six patients including three patients with brain tumor had stable disease.

AB - Forty-two patients with progressive solid tumors and brain tumors were entered in this Phase I study of the glutamine antagonist acivicin given intravenously over thirty minutes daily for five days. The major toxicities encountered were myelosuppression and central nervous system toxicity (nightmares and somnolence). The maximum tolerated dosage on this schedule was 26 mg/M2 daily for five days. Six patients including three patients with brain tumor had stable disease.

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KW - brain tumor

KW - glutamine

KW - glutathione

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A Phase I study of acivicin in refractory pediatric solid tumors - A Pediatric Oncology Group study

Abstract

Keywords

ASJC Scopus subject areas

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