A pH-sensitive eosin-block copolymer delivers proteins intracellularly

Sören Reinhard, Hesong Han, Jan Tuma, Joachim Justad Røise, I. Che Li, Jie Li, Hye Young Lee, Niren Murthy

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

There is great interest in developing strategies to deliver proteins into the cytoplasm of cells. We report here a PEG-poly-eosin block copolymer (PEG-pEosin) that can encapsulate proteins and release them in active form under mildly acidic conditions. A PEG-pEosin formulation composed of Cre and the endosomolytic protein LLO efficiently performed gene editing in cells and in the brains of mice after an intracranial injection. This journal is

Original languageEnglish (US)
Pages (from-to)14207-14210
Number of pages4
JournalChemical Communications
Volume56
Issue number91
DOIs
StatePublished - Nov 25 2020

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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