A perspective on the evolving story of PSMA biology, PSMA-based imaging, and endoradiotherapeutic strategies

Denise S. O'Keefe, Dean J. Bacich, Steve S. Huang, Warren D.W. Heston

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

In this review, we cover the evolution of knowledge on the biology of prostate-specific membrane antigen (PSMA) and its translation to therapy. The usual key to discovery is a realistic model for experimentation and for testing a hypothesis. A realistic model is especially needed in the case of the human prostate, which differs significantly from the prostate of species often used as research models. We will emphasize the genetic characterization of PSMA, the nature of the PSMA protein, and its role as a carboxypeptidase, with differing important substrates and products in different tissues. We give special prominence to the importance of PSMA as a target for imaging and therapy in prostate cancer and its underdeveloped role for imaging and targeting the neovasculature of tumors other than prostate cancer. Lastly, we bring attention to its importance in other nonprostatic tissues.

Original languageEnglish (US)
Pages (from-to)1007-1013
Number of pages7
JournalJournal of Nuclear Medicine
Volume59
Issue number7
DOIs
StatePublished - Jul 1 2018

Keywords

  • Angiogenesis
  • Endoradiotherapy
  • Folate
  • Inflammatory bowel disease
  • Prostate cancer
  • Tumor neovasculature

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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