A perspective on the evolving story of PSMA biology, PSMA-based imaging, and endoradiotherapeutic strategies

Denise S. O'Keefe; Dean J. Bacich; Steve S. Huang; Warren D.W. Heston

doi:10.2967/jnumed.117.203877

A perspective on the evolving story of PSMA biology, PSMA-based imaging, and endoradiotherapeutic strategies

Denise S. O'Keefe, Dean J. Bacich, Steve S. Huang, Warren D.W. Heston

Urology

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

In this review, we cover the evolution of knowledge on the biology of prostate-specific membrane antigen (PSMA) and its translation to therapy. The usual key to discovery is a realistic model for experimentation and for testing a hypothesis. A realistic model is especially needed in the case of the human prostate, which differs significantly from the prostate of species often used as research models. We will emphasize the genetic characterization of PSMA, the nature of the PSMA protein, and its role as a carboxypeptidase, with differing important substrates and products in different tissues. We give special prominence to the importance of PSMA as a target for imaging and therapy in prostate cancer and its underdeveloped role for imaging and targeting the neovasculature of tumors other than prostate cancer. Lastly, we bring attention to its importance in other nonprostatic tissues.

Original language	English (US)
Pages (from-to)	1007-1013
Number of pages	7
Journal	Journal of Nuclear Medicine
Volume	59
Issue number	7
DOIs	https://doi.org/10.2967/jnumed.117.203877
State	Published - Jul 1 2018

Keywords

Angiogenesis
Endoradiotherapy
Folate
Inflammatory bowel disease
Prostate cancer
Tumor neovasculature

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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title = "A perspective on the evolving story of PSMA biology, PSMA-based imaging, and endoradiotherapeutic strategies",

abstract = "In this review, we cover the evolution of knowledge on the biology of prostate-specific membrane antigen (PSMA) and its translation to therapy. The usual key to discovery is a realistic model for experimentation and for testing a hypothesis. A realistic model is especially needed in the case of the human prostate, which differs significantly from the prostate of species often used as research models. We will emphasize the genetic characterization of PSMA, the nature of the PSMA protein, and its role as a carboxypeptidase, with differing important substrates and products in different tissues. We give special prominence to the importance of PSMA as a target for imaging and therapy in prostate cancer and its underdeveloped role for imaging and targeting the neovasculature of tumors other than prostate cancer. Lastly, we bring attention to its importance in other nonprostatic tissues.",

keywords = "Angiogenesis, Endoradiotherapy, Folate, Inflammatory bowel disease, Prostate cancer, Tumor neovasculature",

author = "O'Keefe, {Denise S.} and Bacich, {Dean J.} and Huang, {Steve S.} and Heston, {Warren D.W.}",

note = "Funding Information: This work was supported in part by NIH grant R01 CA138444 to Denise O{\textquoteright}Keefe and Dean Bacich. No other potential conflict of interest relevant to this article was reported.",

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doi = "10.2967/jnumed.117.203877",

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AU - O'Keefe, Denise S.

AU - Bacich, Dean J.

AU - Huang, Steve S.

AU - Heston, Warren D.W.

N1 - Funding Information: This work was supported in part by NIH grant R01 CA138444 to Denise O’Keefe and Dean Bacich. No other potential conflict of interest relevant to this article was reported.

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N2 - In this review, we cover the evolution of knowledge on the biology of prostate-specific membrane antigen (PSMA) and its translation to therapy. The usual key to discovery is a realistic model for experimentation and for testing a hypothesis. A realistic model is especially needed in the case of the human prostate, which differs significantly from the prostate of species often used as research models. We will emphasize the genetic characterization of PSMA, the nature of the PSMA protein, and its role as a carboxypeptidase, with differing important substrates and products in different tissues. We give special prominence to the importance of PSMA as a target for imaging and therapy in prostate cancer and its underdeveloped role for imaging and targeting the neovasculature of tumors other than prostate cancer. Lastly, we bring attention to its importance in other nonprostatic tissues.

AB - In this review, we cover the evolution of knowledge on the biology of prostate-specific membrane antigen (PSMA) and its translation to therapy. The usual key to discovery is a realistic model for experimentation and for testing a hypothesis. A realistic model is especially needed in the case of the human prostate, which differs significantly from the prostate of species often used as research models. We will emphasize the genetic characterization of PSMA, the nature of the PSMA protein, and its role as a carboxypeptidase, with differing important substrates and products in different tissues. We give special prominence to the importance of PSMA as a target for imaging and therapy in prostate cancer and its underdeveloped role for imaging and targeting the neovasculature of tumors other than prostate cancer. Lastly, we bring attention to its importance in other nonprostatic tissues.

KW - Angiogenesis

KW - Endoradiotherapy

KW - Folate

KW - Inflammatory bowel disease

KW - Prostate cancer

KW - Tumor neovasculature

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