A Perfect sTORm: The Role of the Mammalian Target of Rapamycin (mTOR) in Cerebrovascular Dysfunction of Alzheimer's Disease: A Mini-Review

Candice E. Van Skike, Veronica Galvan

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Cerebrovascular dysfunction is detected prior to the onset of cognitive and histopathological changes in Alzheimer's disease (AD). Increasing evidence indicates a critical role of cerebrovascular dysfunction in the initiation and progression of AD. Recent studies identified the mechanistic/mammalian target of rapamycin (mTOR) as a critical effector of cerebrovascular dysfunction in AD. mTOR has a key role in the regulation of metabolism, but some mTOR-dependent mechanisms are uniquely specific to the regulation of cerebrovascular function. These include the regulation of cerebral blood flow, blood-brain barrier integrity and maintenance, neurovascular coupling, and cerebrovascular reactivity. This article examines the available evidence for a role of mTOR-driven cerebrovascular dysfunction in the pathogenesis of AD and of vascular cognitive impairment and dementia (VCID) and highlights the therapeutic potential of targeting mTOR and/or specific downstream effectors for vasculoprotection in AD, VCID, and other age-associated neurological diseases with cerebrovascular etiology.

Original languageEnglish (US)
Pages (from-to)205-211
Number of pages7
JournalGerontology
Volume64
Issue number3
DOIs
StatePublished - Mar 1 2018

Keywords

  • Alzheimer's disease
  • Blood-brain barrier
  • Cerebral blood flow
  • MTOR
  • Neurovascular coupling
  • Rapamycin
  • Vascular density

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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