A paradigm for cancer treatment using the retinoblastoma gene in a mouse model

Alexander Yu Nikitin; Daniel J. Riley; Wen Hwa Lee

doi:10.1111/j.1749-6632.1999.tb09396.x

A paradigm for cancer treatment using the retinoblastoma gene in a mouse model

Alexander Yu Nikitin, Daniel J. Riley, Wen Hwa Lee

Medicine

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Discovery of tumor suppressor genes has provided a rational approach to cancer prevention and treatment. Loss of retinoblastoma susceptibility gene (Rb) function is a rate-limiting event in the development of human and mouse cancers. Establishment of animal models of cancer associated with Rb deficiency allowed us to develop and test long-awaited approaches to genetic correction for treating tumors in vivo. Recent studies demonstrated that (1) prevention of carcinogenesis is achieved by correction of gene copy number in Rb(+/-) mice, and (2) reconstitution of Rb gene functions is sufficient for suppression of neoplasia in immunocompetent mice. These results fulfill a promise of cancer treatment by reconstitution of tumor suppressor function.

Original language	English (US)
Pages (from-to)	12-22
Number of pages	11
Journal	Annals of the New York Academy of Sciences
Volume	886
DOIs	https://doi.org/10.1111/j.1749-6632.1999.tb09396.x
State	Published - Jan 1 1999

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science

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AB - Discovery of tumor suppressor genes has provided a rational approach to cancer prevention and treatment. Loss of retinoblastoma susceptibility gene (Rb) function is a rate-limiting event in the development of human and mouse cancers. Establishment of animal models of cancer associated with Rb deficiency allowed us to develop and test long-awaited approaches to genetic correction for treating tumors in vivo. Recent studies demonstrated that (1) prevention of carcinogenesis is achieved by correction of gene copy number in Rb(+/-) mice, and (2) reconstitution of Rb gene functions is sufficient for suppression of neoplasia in immunocompetent mice. These results fulfill a promise of cancer treatment by reconstitution of tumor suppressor function.

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A paradigm for cancer treatment using the retinoblastoma gene in a mouse model

Abstract

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