A paradigm for cancer treatment using the retinoblastoma gene in a mouse model

Alexander Yu Nikitin, Daniel J. Riley, Wen Hwa Lee

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Discovery of tumor suppressor genes has provided a rational approach to cancer prevention and treatment. Loss of retinoblastoma susceptibility gene (Rb) function is a rate-limiting event in the development of human and mouse cancers. Establishment of animal models of cancer associated with Rb deficiency allowed us to develop and test long-awaited approaches to genetic correction for treating tumors in vivo. Recent studies demonstrated that (1) prevention of carcinogenesis is achieved by correction of gene copy number in Rb(+/-) mice, and (2) reconstitution of Rb gene functions is sufficient for suppression of neoplasia in immunocompetent mice. These results fulfill a promise of cancer treatment by reconstitution of tumor suppressor function.

Original languageEnglish (US)
Pages (from-to)12-22
Number of pages11
JournalAnnals of the New York Academy of Sciences
Volume886
DOIs
StatePublished - Jan 1 1999

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ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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