TY - JOUR
T1 - A novel syndrome of radiation-associated acute myeloid leukemia involving AML1 gene translocations
AU - Hromas, Robert
AU - Shopnick, Rinah
AU - Jumean, Hani George
AU - Bowers, Charles
AU - Varella-Garcia, Marileila
AU - Richkind, Kathleen
PY - 2000/6/15
Y1 - 2000/6/15
N2 - AML1 is a transcriptional activator that is essential for normal hematopoietic development. It is the most frequent target for translocations in acute leukemia. We recently identified 3 patients in whom pancytopenia developed almost 50 years after high-level radiation exposure from nuclear explosions during or after World War II. In all 3 patients, acute myeloid leukemia (AML) eventually developed that had similar characteristics and clinical courses. Cytogenetics from the 3 patients revealed a t(1;21)(p36;q22), a t(18;21)(q21; q22), and at(19;21)(q13.4;q22). By fluorescent in situ hybridization (FISH), all 3 translocations disrupted the AML1 gene. Two of these AML1 translocations, the t(18;21) and the t(19;21), have not been reported previously. It is possible that the AML1 gene is a target for radiation-induced AML. (C) 2000 by The American Society of Hematology.
AB - AML1 is a transcriptional activator that is essential for normal hematopoietic development. It is the most frequent target for translocations in acute leukemia. We recently identified 3 patients in whom pancytopenia developed almost 50 years after high-level radiation exposure from nuclear explosions during or after World War II. In all 3 patients, acute myeloid leukemia (AML) eventually developed that had similar characteristics and clinical courses. Cytogenetics from the 3 patients revealed a t(1;21)(p36;q22), a t(18;21)(q21; q22), and at(19;21)(q13.4;q22). By fluorescent in situ hybridization (FISH), all 3 translocations disrupted the AML1 gene. Two of these AML1 translocations, the t(18;21) and the t(19;21), have not been reported previously. It is possible that the AML1 gene is a target for radiation-induced AML. (C) 2000 by The American Society of Hematology.
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U2 - 10.1182/blood.v95.12.4011
DO - 10.1182/blood.v95.12.4011
M3 - Article
C2 - 10845943
AN - SCOPUS:0034660204
SN - 0006-4971
VL - 95
SP - 4011
EP - 4013
JO - Blood
JF - Blood
IS - 12
ER -