A novel pro-lymphangiogenic function for Th17/IL-17

Sunil K. Chauhan, Yiping Jin, Sunali Goyal, Hyun Soo Lee, Thomas A. Fuchsluger, Hyung Keun Lee, Reza Dana

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

Th17 cells, in addition to their proinflammatory functions, have been recognized as potent inducers of angiogenesis in autoimmune diseases and malignancies. In the present study, we demonstrate distinct mechanisms by which IL-17 induces lymphangiogenesis. Using the mouse cornea micropocket and cell culture assays, our data demonstrate that IL-17 directly promotes growth of lymphatic vessels by inducing increased expression of prolymphangiogenic VEGF-D and proliferation of lymphatic endothelial cells. However, IL-17-induced growth of blood vessels is primarily mediated through IL-1β secretion by IL-17-responsive cells. Furthermore, in vivo blockade of IL-17 in a preclinical model of Th17-dominant autoimmune ocular disease demonstrates a significant reduction in the corneal lymphangiogenesis and in the progression of clinical disease. Taken together, our findings demonstrate a novel prolymphangiogenic function for Th17/IL-17, indicating that IL-17 can promote the progression andamplification of immunity in part through its induction of lymphangiogenesis.

Original languageEnglish (US)
Pages (from-to)4630-4634
Number of pages5
JournalBlood
Volume118
Issue number17
DOIs
StatePublished - Oct 27 2011

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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    Chauhan, S. K., Jin, Y., Goyal, S., Lee, H. S., Fuchsluger, T. A., Lee, H. K., & Dana, R. (2011). A novel pro-lymphangiogenic function for Th17/IL-17. Blood, 118(17), 4630-4634. https://doi.org/10.1182/blood-2011-01-332049