A novel method to fabricate bioabsorbable scaffolds

K. Whang, C. H. Thomas, K. E. Healy, G. Nuber

Research output: Contribution to journalArticle

550 Scopus citations

Abstract

An emulsion freeze-drying method for processing porous biodegradable copolymers of polylactic and polyglycolic acid (PLGA) scaffolds was developed. Scaffold porosity and pore sizes were measured using mercury porosimetry. Foams with porosity in the range 91-95%, median pore diameters ranging from 13 to 35 μm (with larger pore diameters greater than 200 μm), and specific pore area in the range 58-102 m2 g-1 were made by varying processing parameters such as water volume fraction, polymer weight percentage and polymer molecular weight. These scaffolds may find applications as structures that facilitate either tissue regeneration or repair during reconstructive operations.

Original languageEnglish (US)
Pages (from-to)837-842
Number of pages6
JournalPolymer
Volume36
Issue number4
DOIs
StatePublished - 1995

Keywords

  • bioabsorbable polymers
  • emulsion processing
  • tissue engineering

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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    Whang, K., Thomas, C. H., Healy, K. E., & Nuber, G. (1995). A novel method to fabricate bioabsorbable scaffolds. Polymer, 36(4), 837-842. https://doi.org/10.1016/0032-3861(95)93115-3