A novel method to fabricate bioabsorbable scaffolds

K. Whang; C. H. Thomas; K. E. Healy; G. Nuber

doi:10.1016/0032-3861(95)93115-3

A novel method to fabricate bioabsorbable scaffolds

K. Whang, C. H. Thomas, K. E. Healy, G. Nuber

Research output: Contribution to journal › Article › peer-review

612 Scopus citations

Abstract

An emulsion freeze-drying method for processing porous biodegradable copolymers of polylactic and polyglycolic acid (PLGA) scaffolds was developed. Scaffold porosity and pore sizes were measured using mercury porosimetry. Foams with porosity in the range 91-95%, median pore diameters ranging from 13 to 35 μm (with larger pore diameters greater than 200 μm), and specific pore area in the range 58-102 m² g^-1 were made by varying processing parameters such as water volume fraction, polymer weight percentage and polymer molecular weight. These scaffolds may find applications as structures that facilitate either tissue regeneration or repair during reconstructive operations.

Original language	English (US)
Pages (from-to)	837-842
Number of pages	6
Journal	Polymer
Volume	36
Issue number	4
DOIs	https://doi.org/10.1016/0032-3861(95)93115-3
State	Published - 1995
Externally published	Yes

Keywords

bioabsorbable polymers
emulsion processing
tissue engineering

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Materials Chemistry

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10.1016/0032-3861(95)93115-3

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title = "A novel method to fabricate bioabsorbable scaffolds",

abstract = "An emulsion freeze-drying method for processing porous biodegradable copolymers of polylactic and polyglycolic acid (PLGA) scaffolds was developed. Scaffold porosity and pore sizes were measured using mercury porosimetry. Foams with porosity in the range 91-95%, median pore diameters ranging from 13 to 35 μm (with larger pore diameters greater than 200 μm), and specific pore area in the range 58-102 m2 g-1 were made by varying processing parameters such as water volume fraction, polymer weight percentage and polymer molecular weight. These scaffolds may find applications as structures that facilitate either tissue regeneration or repair during reconstructive operations.",

keywords = "bioabsorbable polymers, emulsion processing, tissue engineering",

author = "K. Whang and Thomas, {C. H.} and Healy, {K. E.} and G. Nuber",

note = "Funding Information: This work was supported by a grant from the Department of Orthopedic Surgery at Northwestern University, to G.N. and K.E.H. The assistance of Peter Min during initial experiments is gratefully acknowledged. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1995",

doi = "10.1016/0032-3861(95)93115-3",

language = "English (US)",

volume = "36",

pages = "837--842",

journal = "Polymer",

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TY - JOUR

T1 - A novel method to fabricate bioabsorbable scaffolds

AU - Whang, K.

AU - Thomas, C. H.

AU - Healy, K. E.

AU - Nuber, G.

N1 - Funding Information: This work was supported by a grant from the Department of Orthopedic Surgery at Northwestern University, to G.N. and K.E.H. The assistance of Peter Min during initial experiments is gratefully acknowledged. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1995

Y1 - 1995

N2 - An emulsion freeze-drying method for processing porous biodegradable copolymers of polylactic and polyglycolic acid (PLGA) scaffolds was developed. Scaffold porosity and pore sizes were measured using mercury porosimetry. Foams with porosity in the range 91-95%, median pore diameters ranging from 13 to 35 μm (with larger pore diameters greater than 200 μm), and specific pore area in the range 58-102 m2 g-1 were made by varying processing parameters such as water volume fraction, polymer weight percentage and polymer molecular weight. These scaffolds may find applications as structures that facilitate either tissue regeneration or repair during reconstructive operations.

AB - An emulsion freeze-drying method for processing porous biodegradable copolymers of polylactic and polyglycolic acid (PLGA) scaffolds was developed. Scaffold porosity and pore sizes were measured using mercury porosimetry. Foams with porosity in the range 91-95%, median pore diameters ranging from 13 to 35 μm (with larger pore diameters greater than 200 μm), and specific pore area in the range 58-102 m2 g-1 were made by varying processing parameters such as water volume fraction, polymer weight percentage and polymer molecular weight. These scaffolds may find applications as structures that facilitate either tissue regeneration or repair during reconstructive operations.

KW - bioabsorbable polymers

KW - emulsion processing

KW - tissue engineering

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JO - Polymer

JF - Polymer

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ER -

A novel method to fabricate bioabsorbable scaffolds

Abstract

Keywords

ASJC Scopus subject areas

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