A novel isocyanide/Ag2CO3-promoted addition of heteroatoms to alkynes under mild conditions

Jie Lei; Jia Xu; Ya Fei Luo; Jie Li; Jing Ya Wang; Hong Yu Li; Zhi Gang Xu; Zhong Zhu Chen

doi:10.1039/d2qo01642g

A novel isocyanide/Ag₂CO₃-promoted addition of heteroatoms to alkynes under mild conditions

Jie Lei, Jia Xu, Ya Fei Luo, Jie Li, Jing Ya Wang, Hong Yu Li, Zhi Gang Xu, Zhong Zhu Chen

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A facile and practical isocyanide/Ag₂CO₃-promoted atom-economic addition of heteroatoms to alkynes has been developed for the construction of high-value scaffolds. In contrast to the reported methods, this strategy featured efficient and green characteristics, e.g., broad functional group compatibility, rapid and quantitative conversion, use of an eco-friendly solvent (EtOH), and an isocyanide/Ag₂CO₃ catalytic transformation. Moreover, the catalyst loading of Ag₂CO₃ could be decreased to 1 mol% with the aid of isocyanide. Therefore, in principle, numerous common classes of additions of a nucleophilic element-hydrogen to alkynes could likewise be amenable to this catalyst system.

Original language	English (US)
Pages (from-to)	786-792
Number of pages	7
Journal	Organic Chemistry Frontiers
Volume	10
Issue number	3
DOIs	https://doi.org/10.1039/d2qo01642g
State	Published - Dec 23 2022
Externally published	Yes

ASJC Scopus subject areas

Organic Chemistry

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title = "A novel isocyanide/Ag2CO3-promoted addition of heteroatoms to alkynes under mild conditions",

abstract = "A facile and practical isocyanide/Ag2CO3-promoted atom-economic addition of heteroatoms to alkynes has been developed for the construction of high-value scaffolds. In contrast to the reported methods, this strategy featured efficient and green characteristics, e.g., broad functional group compatibility, rapid and quantitative conversion, use of an eco-friendly solvent (EtOH), and an isocyanide/Ag2CO3 catalytic transformation. Moreover, the catalyst loading of Ag2CO3 could be decreased to 1 mol% with the aid of isocyanide. Therefore, in principle, numerous common classes of additions of a nucleophilic element-hydrogen to alkynes could likewise be amenable to this catalyst system.",

author = "Jie Lei and Jia Xu and Luo, {Ya Fei} and Jie Li and Wang, {Jing Ya} and Li, {Hong Yu} and Xu, {Zhi Gang} and Chen, {Zhong Zhu}",

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doi = "10.1039/d2qo01642g",

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T1 - A novel isocyanide/Ag2CO3-promoted addition of heteroatoms to alkynes under mild conditions

AU - Lei, Jie

AU - Xu, Jia

AU - Luo, Ya Fei

AU - Li, Jie

AU - Wang, Jing Ya

AU - Li, Hong Yu

AU - Xu, Zhi Gang

AU - Chen, Zhong Zhu

PY - 2022/12/23

Y1 - 2022/12/23

N2 - A facile and practical isocyanide/Ag2CO3-promoted atom-economic addition of heteroatoms to alkynes has been developed for the construction of high-value scaffolds. In contrast to the reported methods, this strategy featured efficient and green characteristics, e.g., broad functional group compatibility, rapid and quantitative conversion, use of an eco-friendly solvent (EtOH), and an isocyanide/Ag2CO3 catalytic transformation. Moreover, the catalyst loading of Ag2CO3 could be decreased to 1 mol% with the aid of isocyanide. Therefore, in principle, numerous common classes of additions of a nucleophilic element-hydrogen to alkynes could likewise be amenable to this catalyst system.

AB - A facile and practical isocyanide/Ag2CO3-promoted atom-economic addition of heteroatoms to alkynes has been developed for the construction of high-value scaffolds. In contrast to the reported methods, this strategy featured efficient and green characteristics, e.g., broad functional group compatibility, rapid and quantitative conversion, use of an eco-friendly solvent (EtOH), and an isocyanide/Ag2CO3 catalytic transformation. Moreover, the catalyst loading of Ag2CO3 could be decreased to 1 mol% with the aid of isocyanide. Therefore, in principle, numerous common classes of additions of a nucleophilic element-hydrogen to alkynes could likewise be amenable to this catalyst system.

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A novel isocyanide/Ag₂CO₃-promoted addition of heteroatoms to alkynes under mild conditions

Abstract

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