A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia

Melina Carapeti, Ricardo C.T. Aguiar, John M. Goldman, Nicholas C.P. Cross

Research output: Contribution to journalArticlepeer-review

218 Scopus citations

Abstract

Chromosomal abnormalities of band 8p11 are associated with a distinct subtype of acute myeloid leukemia with French-American-British M4/5 morphology and prominent erythrophagocytosis by the blast cells. This subtype is usually associated with the t(8;16)(p11;p13), a translocation that has recently been shown to result in a fusion between the MOZ and CBP genes. We have cloned the inv(8)(p11q13), an abnormality associated with the same leukemia phenotype, and found a novel fusion between MOZ and the nuclear receptor transcriptional coactivator TIF2/GRIP-1/NCoA-2. This gene has not previously been implicated in the pathogenesis of leukemia or other malignancies. MOZ-TIF2 retains the histone acetyltransferase homology domains of both proteins and also the CBP binding domain of TIF2. We speculate that the apparently identical leukemia cell phenotype observed in cases with the t(8;16) and the inv(8) arises by recruitment of CBP by MOZ-TIF2, resulting in modulation of the transcriptional activity of target genes by a mechanism involving abnormal histone acetylation.

Original languageEnglish (US)
Pages (from-to)3127-3133
Number of pages7
JournalBlood
Volume91
Issue number9
DOIs
StatePublished - May 1 1998

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Fingerprint Dive into the research topics of 'A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia'. Together they form a unique fingerprint.

Cite this