A novel function of adenomatous polyposis coli (APC) in regulating DNA repair

Aruna S. Jaiswal, Satya Narayan

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

Prevailing literature suggests diversified cellular functions for the adenomatous polyposis coli (APC) gene. Among them a recently discovered unique role of APC is in DNA repair. The APC gene can modulate the base excision repair (BER) pathway through an interaction with DNA polymerase β (Pol-β) and flap endonuclease 1 (Fen-1). Taken together with the transcriptional activation of APC gene by alkylating agents and modulation of BER activity, APC may play an important role in carcinogenesis and chemotherapy by determining whether cells with DNA damage survive or undergo apoptosis. In this review, we summarize the evidence supporting this novel concept and suggest that these results will have implications for the development of more effective strategies for chemoprevention, prognosis and chemotherapy of certain types of tumors.

Original languageEnglish (US)
Pages (from-to)272-280
Number of pages9
JournalCancer Letters
Volume271
Issue number2
DOIs
StatePublished - Nov 28 2008
Externally publishedYes

Keywords

  • Adenomatous polyposis coli
  • Base excision repair
  • Carcinogenesis
  • Chemotherapy
  • DNA polymerase β

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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