A novel function of adenomatous polyposis coli (APC) in regulating DNA repair

Aruna S. Jaiswal; Satya Narayan

doi:10.1016/j.canlet.2008.06.024

A novel function of adenomatous polyposis coli (APC) in regulating DNA repair

Aruna S. Jaiswal, Satya Narayan

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Prevailing literature suggests diversified cellular functions for the adenomatous polyposis coli (APC) gene. Among them a recently discovered unique role of APC is in DNA repair. The APC gene can modulate the base excision repair (BER) pathway through an interaction with DNA polymerase β (Pol-β) and flap endonuclease 1 (Fen-1). Taken together with the transcriptional activation of APC gene by alkylating agents and modulation of BER activity, APC may play an important role in carcinogenesis and chemotherapy by determining whether cells with DNA damage survive or undergo apoptosis. In this review, we summarize the evidence supporting this novel concept and suggest that these results will have implications for the development of more effective strategies for chemoprevention, prognosis and chemotherapy of certain types of tumors.

Original language	English (US)
Pages (from-to)	272-280
Number of pages	9
Journal	Cancer Letters
Volume	271
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2008.06.024
State	Published - Nov 28 2008
Externally published	Yes

Keywords

Adenomatous polyposis coli
Base excision repair
Carcinogenesis
Chemotherapy
DNA polymerase β

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.canlet.2008.06.024

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title = "A novel function of adenomatous polyposis coli (APC) in regulating DNA repair",

abstract = "Prevailing literature suggests diversified cellular functions for the adenomatous polyposis coli (APC) gene. Among them a recently discovered unique role of APC is in DNA repair. The APC gene can modulate the base excision repair (BER) pathway through an interaction with DNA polymerase β (Pol-β) and flap endonuclease 1 (Fen-1). Taken together with the transcriptional activation of APC gene by alkylating agents and modulation of BER activity, APC may play an important role in carcinogenesis and chemotherapy by determining whether cells with DNA damage survive or undergo apoptosis. In this review, we summarize the evidence supporting this novel concept and suggest that these results will have implications for the development of more effective strategies for chemoprevention, prognosis and chemotherapy of certain types of tumors.",

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AU - Narayan, Satya

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N2 - Prevailing literature suggests diversified cellular functions for the adenomatous polyposis coli (APC) gene. Among them a recently discovered unique role of APC is in DNA repair. The APC gene can modulate the base excision repair (BER) pathway through an interaction with DNA polymerase β (Pol-β) and flap endonuclease 1 (Fen-1). Taken together with the transcriptional activation of APC gene by alkylating agents and modulation of BER activity, APC may play an important role in carcinogenesis and chemotherapy by determining whether cells with DNA damage survive or undergo apoptosis. In this review, we summarize the evidence supporting this novel concept and suggest that these results will have implications for the development of more effective strategies for chemoprevention, prognosis and chemotherapy of certain types of tumors.

AB - Prevailing literature suggests diversified cellular functions for the adenomatous polyposis coli (APC) gene. Among them a recently discovered unique role of APC is in DNA repair. The APC gene can modulate the base excision repair (BER) pathway through an interaction with DNA polymerase β (Pol-β) and flap endonuclease 1 (Fen-1). Taken together with the transcriptional activation of APC gene by alkylating agents and modulation of BER activity, APC may play an important role in carcinogenesis and chemotherapy by determining whether cells with DNA damage survive or undergo apoptosis. In this review, we summarize the evidence supporting this novel concept and suggest that these results will have implications for the development of more effective strategies for chemoprevention, prognosis and chemotherapy of certain types of tumors.

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KW - Chemotherapy

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A novel function of adenomatous polyposis coli (APC) in regulating DNA repair

Abstract

Keywords

ASJC Scopus subject areas

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