A Novel Full Sense Device to Treat Obesity in a Porcine Model: Preliminary Results

Jung Hoon Park; Nader Bakheet; Hee Kyong Na; Jae Yong Jeon; Sung Hwan Yoon; Kun Yung Kim; Wang Zhe; Do Hoon Kim; Hwoon Yong Jung; Ho Young Song

doi:10.1007/s11695-018-03692-5

A Novel Full Sense Device to Treat Obesity in a Porcine Model: Preliminary Results

Jung Hoon Park, Nader Bakheet, Hee Kyong Na, Jae Yong Jeon, Sung Hwan Yoon, Kun Yung Kim, Wang Zhe, Do Hoon Kim, Hwoon Yong Jung, Ho Young Song

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Purpose: To evaluate the technical feasibility, safety, and efficacy of a novel full sense device (FSD) for the treatment of obesity in a porcine model. Materials and Methods: The novel FSD comprised a self-expanding metallic esophageal stent connected to a star-shaped nitinol disk. Three types of FSD were used: fully covered (type A), fully covered with barbs (type B), and uncovered with barbs (type C). Nine juvenile pigs were divided into two groups: FSD (n = 6) and control (n = 3). FSD type A was placed in the FSD group. In case of migration, either FSD type B or type C was then randomly placed. Food intake was monitored daily. Weight changes and ghrelin hormone levels were monitored weekly for 12 weeks. Results: FSD placement was technically successful in all pigs. All FSDs except one migrated to the stomach within 1 week after placement. The pig in which the FSD was retained showed decreased food intake in the first week after FSD placement, and there was a difference in the final weight between the FSD pig and control pigs. The percentage of weight gain was 116.6% in the control group and 105.3% in the FSD pig. Conclusion: FSD placement under fluoroscopic and endoscopic guidance is technically feasible and safe in a porcine model. The uncovered FSD appears to decrease food intake and reduce the rate of weight gain. However, the high FSD migration rate is not encouraging.

Original language	English (US)
Pages (from-to)	1521-1527
Number of pages	7
Journal	Obesity Surgery
Volume	29
Issue number	5
DOIs	https://doi.org/10.1007/s11695-018-03692-5
State	Published - May 15 2019
Externally published	Yes

Keywords

Full sense device
Ghrelin
Obesity
Weight loss

ASJC Scopus subject areas

Surgery
Endocrinology, Diabetes and Metabolism
Nutrition and Dietetics

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10.1007/s11695-018-03692-5

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A Novel Full Sense Device to Treat Obesity in a Porcine Model : Preliminary Results. / Park, Jung Hoon; Bakheet, Nader; Na, Hee Kyong; Jeon, Jae Yong; Yoon, Sung Hwan; Kim, Kun Yung; Zhe, Wang; Kim, Do Hoon; Jung, Hwoon Yong; Song, Ho Young.

In: Obesity Surgery, Vol. 29, No. 5, 15.05.2019, p. 1521-1527.

Research output: Contribution to journal › Article › peer-review

@article{b788904ebff24fa29965c299cfd606ce,

title = "A Novel Full Sense Device to Treat Obesity in a Porcine Model: Preliminary Results",

abstract = "Purpose: To evaluate the technical feasibility, safety, and efficacy of a novel full sense device (FSD) for the treatment of obesity in a porcine model. Materials and Methods: The novel FSD comprised a self-expanding metallic esophageal stent connected to a star-shaped nitinol disk. Three types of FSD were used: fully covered (type A), fully covered with barbs (type B), and uncovered with barbs (type C). Nine juvenile pigs were divided into two groups: FSD (n = 6) and control (n = 3). FSD type A was placed in the FSD group. In case of migration, either FSD type B or type C was then randomly placed. Food intake was monitored daily. Weight changes and ghrelin hormone levels were monitored weekly for 12 weeks. Results: FSD placement was technically successful in all pigs. All FSDs except one migrated to the stomach within 1 week after placement. The pig in which the FSD was retained showed decreased food intake in the first week after FSD placement, and there was a difference in the final weight between the FSD pig and control pigs. The percentage of weight gain was 116.6% in the control group and 105.3% in the FSD pig. Conclusion: FSD placement under fluoroscopic and endoscopic guidance is technically feasible and safe in a porcine model. The uncovered FSD appears to decrease food intake and reduce the rate of weight gain. However, the high FSD migration rate is not encouraging.",

keywords = "Full sense device, Ghrelin, Obesity, Weight loss",

author = "Park, {Jung Hoon} and Nader Bakheet and Na, {Hee Kyong} and Jeon, {Jae Yong} and Yoon, {Sung Hwan} and Kim, {Kun Yung} and Wang Zhe and Kim, {Do Hoon} and Jung, {Hwoon Yong} and Song, {Ho Young}",

note = "Funding Information: Acknowledgments This study was supported by a grant from the Korean Health Technology R&D Project, Ministry of Health & Welfare, and Republic of Korea (grant no. HI18C0631 to H.Y.J.). Funding Information: This study was approved by the Institutional Animal Care and Use Committee of our institution and conformed to U.S. National Institutes of Health guidelines for humane handling of laboratory animals. Funding Information: This study was supported by a grant from the Korean Health Technology R&D Project, Ministry of Health & Welfare, and Republic of Korea (grant no. HI18C0631 to H.Y.J.). Publisher Copyright: {\textcopyright} 2019, Springer Science+Business Media, LLC, part of Springer Nature.",

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AU - Park, Jung Hoon

AU - Bakheet, Nader

AU - Na, Hee Kyong

AU - Jeon, Jae Yong

AU - Yoon, Sung Hwan

AU - Kim, Kun Yung

AU - Zhe, Wang

AU - Kim, Do Hoon

AU - Jung, Hwoon Yong

AU - Song, Ho Young

N1 - Funding Information: Acknowledgments This study was supported by a grant from the Korean Health Technology R&D Project, Ministry of Health & Welfare, and Republic of Korea (grant no. HI18C0631 to H.Y.J.). Funding Information: This study was approved by the Institutional Animal Care and Use Committee of our institution and conformed to U.S. National Institutes of Health guidelines for humane handling of laboratory animals. Funding Information: This study was supported by a grant from the Korean Health Technology R&D Project, Ministry of Health & Welfare, and Republic of Korea (grant no. HI18C0631 to H.Y.J.). Publisher Copyright: © 2019, Springer Science+Business Media, LLC, part of Springer Nature.

PY - 2019/5/15

Y1 - 2019/5/15

N2 - Purpose: To evaluate the technical feasibility, safety, and efficacy of a novel full sense device (FSD) for the treatment of obesity in a porcine model. Materials and Methods: The novel FSD comprised a self-expanding metallic esophageal stent connected to a star-shaped nitinol disk. Three types of FSD were used: fully covered (type A), fully covered with barbs (type B), and uncovered with barbs (type C). Nine juvenile pigs were divided into two groups: FSD (n = 6) and control (n = 3). FSD type A was placed in the FSD group. In case of migration, either FSD type B or type C was then randomly placed. Food intake was monitored daily. Weight changes and ghrelin hormone levels were monitored weekly for 12 weeks. Results: FSD placement was technically successful in all pigs. All FSDs except one migrated to the stomach within 1 week after placement. The pig in which the FSD was retained showed decreased food intake in the first week after FSD placement, and there was a difference in the final weight between the FSD pig and control pigs. The percentage of weight gain was 116.6% in the control group and 105.3% in the FSD pig. Conclusion: FSD placement under fluoroscopic and endoscopic guidance is technically feasible and safe in a porcine model. The uncovered FSD appears to decrease food intake and reduce the rate of weight gain. However, the high FSD migration rate is not encouraging.

AB - Purpose: To evaluate the technical feasibility, safety, and efficacy of a novel full sense device (FSD) for the treatment of obesity in a porcine model. Materials and Methods: The novel FSD comprised a self-expanding metallic esophageal stent connected to a star-shaped nitinol disk. Three types of FSD were used: fully covered (type A), fully covered with barbs (type B), and uncovered with barbs (type C). Nine juvenile pigs were divided into two groups: FSD (n = 6) and control (n = 3). FSD type A was placed in the FSD group. In case of migration, either FSD type B or type C was then randomly placed. Food intake was monitored daily. Weight changes and ghrelin hormone levels were monitored weekly for 12 weeks. Results: FSD placement was technically successful in all pigs. All FSDs except one migrated to the stomach within 1 week after placement. The pig in which the FSD was retained showed decreased food intake in the first week after FSD placement, and there was a difference in the final weight between the FSD pig and control pigs. The percentage of weight gain was 116.6% in the control group and 105.3% in the FSD pig. Conclusion: FSD placement under fluoroscopic and endoscopic guidance is technically feasible and safe in a porcine model. The uncovered FSD appears to decrease food intake and reduce the rate of weight gain. However, the high FSD migration rate is not encouraging.

KW - Full sense device

KW - Ghrelin

KW - Obesity

KW - Weight loss

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A Novel Full Sense Device to Treat Obesity in a Porcine Model: Preliminary Results

Abstract

Keywords

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