A novel Brucella isolate in association with two cases of stillbirth in non-human primates - First report

Natalia E. Schlabritz-Loutsevitch; Adrian M. Whatmore; Christine R. Quance; Mark S. Koylass; L. Bill Cummins; Edward J. Dick; Cathy L. Snider; David Cappelli; Jeffrey L. Ebersole; Peter W. Nathanielsz; Gene B. Hubbard

doi:10.1111/j.1600-0684.2008.00314.x

A novel Brucella isolate in association with two cases of stillbirth in non-human primates - First report

Natalia E. Schlabritz-Loutsevitch, Adrian M. Whatmore, Christine R. Quance, Mark S. Koylass, L. Bill Cummins, Edward J. Dick, Cathy L. Snider, David Cappelli, Jeffrey L. Ebersole, Peter W. Nathanielsz, Gene B. Hubbard

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Background: Brucellosis is veterinary and human health problem. Methods: A 13-year-old wild caught multiparous and an 8-year-old colony-born nulliparous baboon had stillbirths in the second trimester of pregnancy. Culture isolates from both postpartum uteruses were characterized using traditional biochemical analysis, PCR, and multilocus sequencing. Results: The isolates morphologically resembled Brucella although their phenotypic characteristics were not consistent with any currently described species. The isolates represent a novel lineage within the genus with unique alleles, not previously seen in surveys of greater than 300 isolates representing the known diversity of the genus, present at 5/9 loci examined. Conclusions: The described cases are to the best of our knowledge the first presentation of a naturally acquired Brucella infection in non-human primates associated with stillbirths from the same colony where Brucella seropositivity in the baboons was described 45 years ago. The organism appears to represent a previously undescribed Brucella species.

Original language	English (US)
Pages (from-to)	70-73
Number of pages	4
Journal	Journal of medical primatology
Volume	38
Issue number	1
DOIs	https://doi.org/10.1111/j.1600-0684.2008.00314.x
State	Published - 2009

Keywords

Brucella
Non-human primates
Stillbirth

ASJC Scopus subject areas

Animal Science and Zoology
veterinary(all)

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10.1111/j.1600-0684.2008.00314.x

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Schlabritz-Loutsevitch, N. E., Whatmore, A. M., Quance, C. R., Koylass, M. S., Cummins, L. B., Dick, E. J., Snider, C. L., Cappelli, D., Ebersole, J. L., Nathanielsz, P. W., & Hubbard, G. B. (2009). A novel Brucella isolate in association with two cases of stillbirth in non-human primates - First report. Journal of medical primatology, 38(1), 70-73. https://doi.org/10.1111/j.1600-0684.2008.00314.x

Schlabritz-Loutsevitch, NE, Whatmore, AM, Quance, CR, Koylass, MS, Cummins, LB, Dick, EJ, Snider, CL, Cappelli, D, Ebersole, JL, Nathanielsz, PW & Hubbard, GB 2009, 'A novel Brucella isolate in association with two cases of stillbirth in non-human primates - First report', Journal of medical primatology, vol. 38, no. 1, pp. 70-73. https://doi.org/10.1111/j.1600-0684.2008.00314.x

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abstract = "Background: Brucellosis is veterinary and human health problem. Methods: A 13-year-old wild caught multiparous and an 8-year-old colony-born nulliparous baboon had stillbirths in the second trimester of pregnancy. Culture isolates from both postpartum uteruses were characterized using traditional biochemical analysis, PCR, and multilocus sequencing. Results: The isolates morphologically resembled Brucella although their phenotypic characteristics were not consistent with any currently described species. The isolates represent a novel lineage within the genus with unique alleles, not previously seen in surveys of greater than 300 isolates representing the known diversity of the genus, present at 5/9 loci examined. Conclusions: The described cases are to the best of our knowledge the first presentation of a naturally acquired Brucella infection in non-human primates associated with stillbirths from the same colony where Brucella seropositivity in the baboons was described 45 years ago. The organism appears to represent a previously undescribed Brucella species.",

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doi = "10.1111/j.1600-0684.2008.00314.x",

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AU - Whatmore, Adrian M.

AU - Quance, Christine R.

AU - Koylass, Mark S.

AU - Cummins, L. Bill

AU - Dick, Edward J.

AU - Snider, Cathy L.

AU - Cappelli, David

AU - Ebersole, Jeffrey L.

AU - Nathanielsz, Peter W.

AU - Hubbard, Gene B.

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AB - Background: Brucellosis is veterinary and human health problem. Methods: A 13-year-old wild caught multiparous and an 8-year-old colony-born nulliparous baboon had stillbirths in the second trimester of pregnancy. Culture isolates from both postpartum uteruses were characterized using traditional biochemical analysis, PCR, and multilocus sequencing. Results: The isolates morphologically resembled Brucella although their phenotypic characteristics were not consistent with any currently described species. The isolates represent a novel lineage within the genus with unique alleles, not previously seen in surveys of greater than 300 isolates representing the known diversity of the genus, present at 5/9 loci examined. Conclusions: The described cases are to the best of our knowledge the first presentation of a naturally acquired Brucella infection in non-human primates associated with stillbirths from the same colony where Brucella seropositivity in the baboons was described 45 years ago. The organism appears to represent a previously undescribed Brucella species.

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KW - Non-human primates

KW - Stillbirth

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A novel Brucella isolate in association with two cases of stillbirth in non-human primates - First report

Abstract

Keywords

ASJC Scopus subject areas

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