A novel Brucella isolate in association with two cases of stillbirth in non-human primates - First report

Natalia E. Schlabritz-Loutsevitch, Adrian M. Whatmore, Christine R. Quance, Mark S. Koylass, L. Bill Cummins, Edward J. Dick, Cathy L. Snider, David P Cappelli, Jeffrey L. Ebersole, Peter W. Nathanielsz, Gene B. Hubbard

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Background: Brucellosis is veterinary and human health problem. Methods: A 13-year-old wild caught multiparous and an 8-year-old colony-born nulliparous baboon had stillbirths in the second trimester of pregnancy. Culture isolates from both postpartum uteruses were characterized using traditional biochemical analysis, PCR, and multilocus sequencing. Results: The isolates morphologically resembled Brucella although their phenotypic characteristics were not consistent with any currently described species. The isolates represent a novel lineage within the genus with unique alleles, not previously seen in surveys of greater than 300 isolates representing the known diversity of the genus, present at 5/9 loci examined. Conclusions: The described cases are to the best of our knowledge the first presentation of a naturally acquired Brucella infection in non-human primates associated with stillbirths from the same colony where Brucella seropositivity in the baboons was described 45 years ago. The organism appears to represent a previously undescribed Brucella species.

Original languageEnglish (US)
Pages (from-to)70-73
Number of pages4
JournalJournal of medical primatology
Volume38
Issue number1
DOIs
StatePublished - 2009

Keywords

  • Brucella
  • Non-human primates
  • Stillbirth

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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