A new suggested strategy for safe injection of ozurdex

Chelsey J. Krambeer, Kendall W. Wannamaker, Wayne Tie, Sepehr Bahadorani, Julia Singer, Stan Conston, Michael A. Singer

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

BACKGROUND AND OBJECTIVES: Ozurdex intravitreal injection is performed via a patented injection device. However, there is a common misconception among ophthalmologists regarding the relation between the speed of applicator button depression and the speed of pellet injection. PATIENTS AND METHODS: Six dexamethasone intravitreal implants were injected into a calibrated ex vivo water bath. Three of the pellets were injected via rapid compression, whereas the other three implants were injected using a 3-second compression technique. The procedures were recorded using high-speed photography followed by calculation of pellet velocity and impact force. RESULTS: The mean impact velocity and force of the pellet insertion is significantly higher in the fast injection group compared to the slow injection group. CONCLUSIONS: By depressing the Ozurdex implant injector during a 3-second time interval, the impact force of the implant pellet is reduced by about 95%. This new technique will theoretically reduce the risk of retinal injury and vitreous hemorrhage from Ozurdex injections.

Original languageEnglish (US)
Pages (from-to)E23-E25
JournalOphthalmic Surgery Lasers and Imaging Retina
Volume50
Issue number2
DOIs
StatePublished - Feb 2019

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

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