A new suggested strategy for safe injection of ozurdex

Chelsey J. Krambeer; Kendall W. Wannamaker; Wayne Tie; Sepehr Bahadorani; Julia Singer; Stan Conston; Michael A. Singer

doi:10.3928/23258160-20190129-14

A new suggested strategy for safe injection of ozurdex

Chelsey J. Krambeer, Kendall W. Wannamaker, Wayne Tie, Sepehr Bahadorani, Julia Singer, Stan Conston, Michael A. Singer

Department of Ophthalmology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

BACKGROUND AND OBJECTIVES: Ozurdex intravitreal injection is performed via a patented injection device. However, there is a common misconception among ophthalmologists regarding the relation between the speed of applicator button depression and the speed of pellet injection. PATIENTS AND METHODS: Six dexamethasone intravitreal implants were injected into a calibrated ex vivo water bath. Three of the pellets were injected via rapid compression, whereas the other three implants were injected using a 3-second compression technique. The procedures were recorded using high-speed photography followed by calculation of pellet velocity and impact force. RESULTS: The mean impact velocity and force of the pellet insertion is significantly higher in the fast injection group compared to the slow injection group. CONCLUSIONS: By depressing the Ozurdex implant injector during a 3-second time interval, the impact force of the implant pellet is reduced by about 95%. This new technique will theoretically reduce the risk of retinal injury and vitreous hemorrhage from Ozurdex injections.

Original language	English (US)
Pages (from-to)	E23-E25
Journal	Ophthalmic Surgery Lasers and Imaging Retina
Volume	50
Issue number	2
DOIs	https://doi.org/10.3928/23258160-20190129-14
State	Published - Feb 2019

ASJC Scopus subject areas

Surgery
Ophthalmology

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title = "A new suggested strategy for safe injection of ozurdex",

abstract = "BACKGROUND AND OBJECTIVES: Ozurdex intravitreal injection is performed via a patented injection device. However, there is a common misconception among ophthalmologists regarding the relation between the speed of applicator button depression and the speed of pellet injection. PATIENTS AND METHODS: Six dexamethasone intravitreal implants were injected into a calibrated ex vivo water bath. Three of the pellets were injected via rapid compression, whereas the other three implants were injected using a 3-second compression technique. The procedures were recorded using high-speed photography followed by calculation of pellet velocity and impact force. RESULTS: The mean impact velocity and force of the pellet insertion is significantly higher in the fast injection group compared to the slow injection group. CONCLUSIONS: By depressing the Ozurdex implant injector during a 3-second time interval, the impact force of the implant pellet is reduced by about 95%. This new technique will theoretically reduce the risk of retinal injury and vitreous hemorrhage from Ozurdex injections.",

author = "Krambeer, {Chelsey J.} and Wannamaker, {Kendall W.} and Wayne Tie and Sepehr Bahadorani and Julia Singer and Stan Conston and Singer, {Michael A.}",

note = "Publisher Copyright: {\textcopyright} 2019 Krambeer, Wannamaker, Tie, et al.",

year = "2019",

month = feb,

doi = "10.3928/23258160-20190129-14",

language = "English (US)",

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T1 - A new suggested strategy for safe injection of ozurdex

AU - Krambeer, Chelsey J.

AU - Wannamaker, Kendall W.

AU - Tie, Wayne

AU - Bahadorani, Sepehr

AU - Singer, Julia

AU - Conston, Stan

AU - Singer, Michael A.

PY - 2019/2

Y1 - 2019/2

N2 - BACKGROUND AND OBJECTIVES: Ozurdex intravitreal injection is performed via a patented injection device. However, there is a common misconception among ophthalmologists regarding the relation between the speed of applicator button depression and the speed of pellet injection. PATIENTS AND METHODS: Six dexamethasone intravitreal implants were injected into a calibrated ex vivo water bath. Three of the pellets were injected via rapid compression, whereas the other three implants were injected using a 3-second compression technique. The procedures were recorded using high-speed photography followed by calculation of pellet velocity and impact force. RESULTS: The mean impact velocity and force of the pellet insertion is significantly higher in the fast injection group compared to the slow injection group. CONCLUSIONS: By depressing the Ozurdex implant injector during a 3-second time interval, the impact force of the implant pellet is reduced by about 95%. This new technique will theoretically reduce the risk of retinal injury and vitreous hemorrhage from Ozurdex injections.

AB - BACKGROUND AND OBJECTIVES: Ozurdex intravitreal injection is performed via a patented injection device. However, there is a common misconception among ophthalmologists regarding the relation between the speed of applicator button depression and the speed of pellet injection. PATIENTS AND METHODS: Six dexamethasone intravitreal implants were injected into a calibrated ex vivo water bath. Three of the pellets were injected via rapid compression, whereas the other three implants were injected using a 3-second compression technique. The procedures were recorded using high-speed photography followed by calculation of pellet velocity and impact force. RESULTS: The mean impact velocity and force of the pellet insertion is significantly higher in the fast injection group compared to the slow injection group. CONCLUSIONS: By depressing the Ozurdex implant injector during a 3-second time interval, the impact force of the implant pellet is reduced by about 95%. This new technique will theoretically reduce the risk of retinal injury and vitreous hemorrhage from Ozurdex injections.

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A new suggested strategy for safe injection of ozurdex

Abstract

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