A new perspective in Oral health

Potential importance and actions of melatonin receptors MT1, MT2, MT3, and RZR/ROR in the oral cavity

Antonio Cutando, Jose Aneiros-Fernández, Antonio López-Valverde, Salvador Arias-Santiago, Jose Aneiros-Cachaza, Russel J Reiter

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Background: Melatonin is involved in many physiological processes in mammals, amongst others; it is implicated in sleep-wake regulation. It has antioxidant and anti-inflammatory properties. It also acts as an immunomodulator, stimulates bone metabolism and inhibits various tumours. Additionally an abnormal melatonin rhythm may contribute to depression and insomnia. The mechanisms of action of melatonin include the involvement of membrane receptors (MT1, MT2), cytosolic binding sites (MT3 and calmodulin), and nuclear receptors of the RZR/ROR family. Melatonin also has receptor-independent activity and can directly scavenge free radicals. The current review addresses the functions of melatonin in the oral cavity in relation to its receptors. Methods: An extensive search was conducted on the following scientific databases Pub Med, Science Direct, ISI Web of Knowledge and Cochrane database in order to review all pertinent literature. Results: Melatonin from the blood into the saliva may play an important role in suppressing oral diseases. It may have beneficial effects in periodontal disease, herpes and oral cancer, amongst others. Conclusions: Melatonin contributes to protecting of oral cavity from tissue damage due to its action of different receptors. From the reviewed literature it is concluded that experimental evidence suggests that melatonin can be useful in treating several common diseases of the oral cavity. Specific studies are necessary to extend the therapeutic possibilities of melatonin to other oral diseases.

Original languageEnglish (US)
Pages (from-to)944-950
Number of pages7
JournalArchives of Oral Biology
Volume56
Issue number10
DOIs
StatePublished - Oct 2011
Externally publishedYes

Fingerprint

Melatonin MT1 Receptor
Melatonin MT2 Receptor
Oral Health
Melatonin
Action Potentials
Mouth
Mouth Diseases
Databases
Melatonin Receptors
Physiological Phenomena
Mouth Neoplasms
Immunologic Factors
Sleep Initiation and Maintenance Disorders
Periodontal Diseases
Calmodulin
Cytoplasmic and Nuclear Receptors
Saliva
Free Radicals
Mammals
Sleep

Keywords

  • Cancer oral cavity
  • Melatonin
  • MT1
  • MT2
  • MT3
  • Periodontal
  • Pineal
  • RZR/ROR

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Cell Biology
  • Dentistry(all)

Cite this

A new perspective in Oral health : Potential importance and actions of melatonin receptors MT1, MT2, MT3, and RZR/ROR in the oral cavity. / Cutando, Antonio; Aneiros-Fernández, Jose; López-Valverde, Antonio; Arias-Santiago, Salvador; Aneiros-Cachaza, Jose; Reiter, Russel J.

In: Archives of Oral Biology, Vol. 56, No. 10, 10.2011, p. 944-950.

Research output: Contribution to journalArticle

Cutando, Antonio ; Aneiros-Fernández, Jose ; López-Valverde, Antonio ; Arias-Santiago, Salvador ; Aneiros-Cachaza, Jose ; Reiter, Russel J. / A new perspective in Oral health : Potential importance and actions of melatonin receptors MT1, MT2, MT3, and RZR/ROR in the oral cavity. In: Archives of Oral Biology. 2011 ; Vol. 56, No. 10. pp. 944-950.
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