A new myeloproliferative disorder associated with chromosomal translocations involving 8p11: A review

D. Macdonald, R. C.T. Aguiar, P. J. Mason, J. M. Goldman, N. C.P. Cross

Research output: Contribution to journalShort surveypeer-review

123 Scopus citations

Abstract

Chromosomal breakpoints associated with malignancy are known to cluster at particular regions of the karyotype. Based on a review of the literature we have identified a novel leukaemia syndrome associated with translocations involving 8p11. This syndrome is distinct from the previously described translocation t(8;16)(p11;p13) associated with acute monoblastic leukaemia. We have summarized the clinical and cytogenetic features of 13 case reports which describe a myeloproliferative syndrome with eosinophilia, lymphadenopathy and a high incidence of T cell non-Hodgkin's lymphoma with progression to acute myeloid leukaemia. The translocations involving 8p11 were: either t(8;13)(p11-12;q11-12), t(8;9) (p11;q32-34) or t(6;8)(q27;p12). In two cases of t(8;13) molecular studies have mapped the chromosome 13 breakpoint to a 1.5 Mbp region, but a full molecular characterization of these translocations is required. In view of the striking clinicopathological and karyotypic similarities between these cases we propose that they be considered a single nosological entity and termed '8p11 myeloproliferative syndrome'.

Original languageEnglish (US)
Pages (from-to)1628-1630
Number of pages3
JournalLeukemia
Volume9
Issue number10
StatePublished - Oct 1995
Externally publishedYes

Keywords

  • Chromosome 8
  • Myeloproliferative
  • Translocation

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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