A new member of the acid-sensing ion channel family

Armen N. Akopian, Chih Cheng Chen, Yanning Ding, Paolo Cesare, John N. Wood

Research output: Contribution to journalArticlepeer-review

166 Scopus citations

Abstract

Acid-sensing ion channels (ASICs) are members of the epithelial sodium channel (ENaC)-degenerin family of two-pass transmembrane segment protein subunits which form multimeric cation channels. Members of the ENaC-degenerin family are gated by stimuli as diverse as protons, peptides and mechanical distension. Here we describe a new member of the family, SPASIC or ASIC 4 (spinal cord ASIC) which is expressed throughout the central nervous system in an overlapping population of neurons that also express the ASIC subunit MDEG2. ASIC-4 which shows 44% identify with ASIC is developmentally regulated and expressed in a subset of sensory neurons as well as in the CNS. However, despite the strong homology with ASIC, the ASIC-4 transcript does not encode a proton gated cation channel. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish (US)
Pages (from-to)2217-2222
Number of pages6
JournalNeuroReport
Volume11
Issue number10
DOIs
StatePublished - Jul 14 2000
Externally publishedYes

Keywords

  • Amiloride
  • CNS
  • Degenerins
  • Protons
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

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