A neural signature of metabolic syndrome

Eithan Kotkowski, Larry R. Price, Crystal Franklin, Maximino Salazar, Mary Woolsey, Ralph A Defronzo, John Blangero, David C. Glahn, Peter T Fox

Research output: Contribution to journalArticle

Abstract

That metabolic syndrome (MetS) is associated with age-related cognitive decline is well established. The neurobiological changes underlying these cognitive deficits, however, are not well understood. The goal of this study was to determine whether MetS is associated with regional differences in gray-matter volume (GMV) using a cross-sectional, between-group contrast design in a large, ethnically homogenous sample. T1-weighted MRIs were sampled from the genetics of brain structure (GOBS) data archive for 208 Mexican-American participants: 104 participants met or exceeded standard criteria for MetS and 104 participants were age- and sex-matched metabolically healthy controls. Participants ranged in age from 18 to 74 years (37.3 ± 13.2 years, 56.7% female). Images were analyzed in a whole-brain, voxel-wise manner using voxel-based morphometry (VBM). Three contrast analyses were performed, a whole sample analysis of all 208 participants, and two post hoc half-sample analyses split by age along the median (35.5 years). Significant associations between MetS and decreased GMV were observed in multiple, spatially discrete brain regions including the posterior cerebellum, brainstem, orbitofrontal cortex, bilateral caudate nuclei, right parahippocampus, right amygdala, right insula, lingual gyrus, and right superior temporal gyrus. Age, as shown in the post hoc analyses, was demonstrated to be a significant covariate. A further functional interpretation of the structures exhibiting lower GMV in MetS reflected a significant involvement in reward perception, emotional valence, and reasoning. Additional studies are needed to characterize the influence of MetS's individual clinical components on brain structure and to explore the bidirectional association between GMV and MetS.

Original languageEnglish (US)
JournalHuman Brain Mapping
DOIs
StatePublished - Jan 1 2019

Fingerprint

Brain
Occipital Lobe
Caudate Nucleus
Genetic Structures
Temporal Lobe
Amygdala
Prefrontal Cortex
Reward
Cerebellum
Brain Stem
Gray Matter
Cognitive Dysfunction

Keywords

  • genetics of brain structure
  • GOBS
  • gray matter volume
  • hypercholesterolemia
  • hyperglycemia
  • hypertension
  • hypertriglyceridemia
  • insulin resistance
  • insulin resistance syndrome
  • metabolic syndrome
  • MetS
  • Mexican-American
  • neuroimaging
  • obesity
  • T2DM
  • Type II diabetes mellitus
  • VBM
  • voxel-based morphometry
  • waist circumference

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

A neural signature of metabolic syndrome. / Kotkowski, Eithan; Price, Larry R.; Franklin, Crystal; Salazar, Maximino; Woolsey, Mary; Defronzo, Ralph A; Blangero, John; Glahn, David C.; Fox, Peter T.

In: Human Brain Mapping, 01.01.2019.

Research output: Contribution to journalArticle

Kotkowski, E, Price, LR, Franklin, C, Salazar, M, Woolsey, M, Defronzo, RA, Blangero, J, Glahn, DC & Fox, PT 2019, 'A neural signature of metabolic syndrome', Human Brain Mapping. https://doi.org/10.1002/hbm.24617
Kotkowski E, Price LR, Franklin C, Salazar M, Woolsey M, Defronzo RA et al. A neural signature of metabolic syndrome. Human Brain Mapping. 2019 Jan 1. https://doi.org/10.1002/hbm.24617
Kotkowski, Eithan ; Price, Larry R. ; Franklin, Crystal ; Salazar, Maximino ; Woolsey, Mary ; Defronzo, Ralph A ; Blangero, John ; Glahn, David C. ; Fox, Peter T. / A neural signature of metabolic syndrome. In: Human Brain Mapping. 2019.
@article{ce238cc2ee464557a944a68bbe98d668,
title = "A neural signature of metabolic syndrome",
abstract = "That metabolic syndrome (MetS) is associated with age-related cognitive decline is well established. The neurobiological changes underlying these cognitive deficits, however, are not well understood. The goal of this study was to determine whether MetS is associated with regional differences in gray-matter volume (GMV) using a cross-sectional, between-group contrast design in a large, ethnically homogenous sample. T1-weighted MRIs were sampled from the genetics of brain structure (GOBS) data archive for 208 Mexican-American participants: 104 participants met or exceeded standard criteria for MetS and 104 participants were age- and sex-matched metabolically healthy controls. Participants ranged in age from 18 to 74 years (37.3 ± 13.2 years, 56.7{\%} female). Images were analyzed in a whole-brain, voxel-wise manner using voxel-based morphometry (VBM). Three contrast analyses were performed, a whole sample analysis of all 208 participants, and two post hoc half-sample analyses split by age along the median (35.5 years). Significant associations between MetS and decreased GMV were observed in multiple, spatially discrete brain regions including the posterior cerebellum, brainstem, orbitofrontal cortex, bilateral caudate nuclei, right parahippocampus, right amygdala, right insula, lingual gyrus, and right superior temporal gyrus. Age, as shown in the post hoc analyses, was demonstrated to be a significant covariate. A further functional interpretation of the structures exhibiting lower GMV in MetS reflected a significant involvement in reward perception, emotional valence, and reasoning. Additional studies are needed to characterize the influence of MetS's individual clinical components on brain structure and to explore the bidirectional association between GMV and MetS.",
keywords = "genetics of brain structure, GOBS, gray matter volume, hypercholesterolemia, hyperglycemia, hypertension, hypertriglyceridemia, insulin resistance, insulin resistance syndrome, metabolic syndrome, MetS, Mexican-American, neuroimaging, obesity, T2DM, Type II diabetes mellitus, VBM, voxel-based morphometry, waist circumference",
author = "Eithan Kotkowski and Price, {Larry R.} and Crystal Franklin and Maximino Salazar and Mary Woolsey and Defronzo, {Ralph A} and John Blangero and Glahn, {David C.} and Fox, {Peter T}",
year = "2019",
month = "1",
day = "1",
doi = "10.1002/hbm.24617",
language = "English (US)",
journal = "Human Brain Mapping",
issn = "1065-9471",
publisher = "Wiley-Liss Inc.",

}

TY - JOUR

T1 - A neural signature of metabolic syndrome

AU - Kotkowski, Eithan

AU - Price, Larry R.

AU - Franklin, Crystal

AU - Salazar, Maximino

AU - Woolsey, Mary

AU - Defronzo, Ralph A

AU - Blangero, John

AU - Glahn, David C.

AU - Fox, Peter T

PY - 2019/1/1

Y1 - 2019/1/1

N2 - That metabolic syndrome (MetS) is associated with age-related cognitive decline is well established. The neurobiological changes underlying these cognitive deficits, however, are not well understood. The goal of this study was to determine whether MetS is associated with regional differences in gray-matter volume (GMV) using a cross-sectional, between-group contrast design in a large, ethnically homogenous sample. T1-weighted MRIs were sampled from the genetics of brain structure (GOBS) data archive for 208 Mexican-American participants: 104 participants met or exceeded standard criteria for MetS and 104 participants were age- and sex-matched metabolically healthy controls. Participants ranged in age from 18 to 74 years (37.3 ± 13.2 years, 56.7% female). Images were analyzed in a whole-brain, voxel-wise manner using voxel-based morphometry (VBM). Three contrast analyses were performed, a whole sample analysis of all 208 participants, and two post hoc half-sample analyses split by age along the median (35.5 years). Significant associations between MetS and decreased GMV were observed in multiple, spatially discrete brain regions including the posterior cerebellum, brainstem, orbitofrontal cortex, bilateral caudate nuclei, right parahippocampus, right amygdala, right insula, lingual gyrus, and right superior temporal gyrus. Age, as shown in the post hoc analyses, was demonstrated to be a significant covariate. A further functional interpretation of the structures exhibiting lower GMV in MetS reflected a significant involvement in reward perception, emotional valence, and reasoning. Additional studies are needed to characterize the influence of MetS's individual clinical components on brain structure and to explore the bidirectional association between GMV and MetS.

AB - That metabolic syndrome (MetS) is associated with age-related cognitive decline is well established. The neurobiological changes underlying these cognitive deficits, however, are not well understood. The goal of this study was to determine whether MetS is associated with regional differences in gray-matter volume (GMV) using a cross-sectional, between-group contrast design in a large, ethnically homogenous sample. T1-weighted MRIs were sampled from the genetics of brain structure (GOBS) data archive for 208 Mexican-American participants: 104 participants met or exceeded standard criteria for MetS and 104 participants were age- and sex-matched metabolically healthy controls. Participants ranged in age from 18 to 74 years (37.3 ± 13.2 years, 56.7% female). Images were analyzed in a whole-brain, voxel-wise manner using voxel-based morphometry (VBM). Three contrast analyses were performed, a whole sample analysis of all 208 participants, and two post hoc half-sample analyses split by age along the median (35.5 years). Significant associations between MetS and decreased GMV were observed in multiple, spatially discrete brain regions including the posterior cerebellum, brainstem, orbitofrontal cortex, bilateral caudate nuclei, right parahippocampus, right amygdala, right insula, lingual gyrus, and right superior temporal gyrus. Age, as shown in the post hoc analyses, was demonstrated to be a significant covariate. A further functional interpretation of the structures exhibiting lower GMV in MetS reflected a significant involvement in reward perception, emotional valence, and reasoning. Additional studies are needed to characterize the influence of MetS's individual clinical components on brain structure and to explore the bidirectional association between GMV and MetS.

KW - genetics of brain structure

KW - GOBS

KW - gray matter volume

KW - hypercholesterolemia

KW - hyperglycemia

KW - hypertension

KW - hypertriglyceridemia

KW - insulin resistance

KW - insulin resistance syndrome

KW - metabolic syndrome

KW - MetS

KW - Mexican-American

KW - neuroimaging

KW - obesity

KW - T2DM

KW - Type II diabetes mellitus

KW - VBM

KW - voxel-based morphometry

KW - waist circumference

UR - http://www.scopus.com/inward/record.url?scp=85065481450&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065481450&partnerID=8YFLogxK

U2 - 10.1002/hbm.24617

DO - 10.1002/hbm.24617

M3 - Article

JO - Human Brain Mapping

JF - Human Brain Mapping

SN - 1065-9471

ER -