A national internet-based survey of cerebral aneurysm preference-based quality of life

OBJECTIVE: Preference-based quality of life (QOL) instruments integrate all factors contributing to QOL and provide a comprehensive valuation of a health state. QOL values of the general public for cerebral aneurysm health states are not well understood. METHODS: In an internet-based survey of a nationally representative sample of the United States population, we measured standard gamble QOL values for the subjects' own health and for low-, medium-, and high-risk cerebral aneurysm health state scenarios and determined the effect of depicting aneurysm-associated stroke and death risk as annual or cumulative. RESULTS: The 1654 subjects matched the United States population demographics. The subjects' mean (standard deviation) QOL for their current health was 0.82 (0.19), and for a cerebral aneurysm it was 0.78 (0.19) (P< 0.001). Mean low-, medium-, and high- risk aneurysm QOL values were 0.01, 0.06, and 0.13 lower than for current health, respectively (P < 0.001). The average discrepancy between aneurysm QOL and cur- ! rent health narrowed with age: 18 to 25 years, 0.09; 24 to 44 years, 0.06; 45 to 64 years, 0.03; and 65+ years, 0.01 itrend P< 0.001). Subjects who received only annual risk data provided the highest mean aneurysm QOL values (0.81 [0.18]); those who received both annual and 20-year cumulative risk information gave intermediate values (0.79 [0.18]), and those who received only data on cumulative 20-year risk provided the lowest values (0.76 [0.20]) {P < 0.001). CONCLUSION: Preference-based QOL values for cerebral aneurysms derived from ' the general public vary with the subjects' age, the risk of aneurysmal stroke and death, and the mathematical terminology used to convey the risk of stroke and death.