A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice

Setsu Endoh-Yamagami, Kameel M. Karkar, Scott R. May, Inma Cobos, Myo T. Thwin, Jason E. Long, Amir M. Ashique, Konstantinos Zarbalis, John L.R. Rubenstein, Andrew S. Peterson

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Precise control of neuronal migration is essential for proper function of the brain. Taking a forward genetic screen, we isolated a mutant mouse with defects in interneuron migration. By genetic mapping, we identified a frame shift mutation in the pericentrin (Pcnt) gene. The Pcnt gene encodes a large centrosomal coiled-coil protein that has been implicated in schizophrenia. Recently, frame shift and premature termination mutations in the pericentrin (PCNT) gene were identified in individuals with Seckel syndrome and microcephalic osteodysplastic primordial dwarfism (MOPD II), both of which are characterized by greatly reduced body and brain sizes. The mouse Pcnt mutant shares features with the human syndromes in its overall growth retardation and reduced brain size. We found that dorsal lateral ganglionic eminence (dLGE)-derived olfactory bulb interneurons are severely affected and distributed abnormally in the rostral forebrain in the mutant. Furthermore, mutant interneurons exhibit abnormal migration behavior and RNA interference knockdown of Pcnt impairs cell migration along the rostal migratory stream (RMS) into the olfactory bulb. These findings indicate that pericentrin is required for proper migration of olfactory bulb interneurons and provide a developmental basis for association of pericentrin function with interneuron defects in human schizophrenia.

Original languageEnglish (US)
Pages (from-to)41-53
Number of pages13
JournalDevelopmental Biology
Issue number1
StatePublished - Apr 1 2010
Externally publishedYes


  • Brain development
  • Interneuron migration
  • Microcephalic osteodysplastic primordial dwarfism (MOPD)
  • Olfactory bulb
  • Pericentrin
  • Rostral migratory stream (RMS)
  • Schizophrenia
  • Seckel syndrome

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology


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