A multimodal assessment of the genetic control over working memory

Katherine H. Karlsgodt, Peter Kochunov, Anderson M. Winkler, Angela R. Laird, Laura Almasy, Ravindranath Duggirala, Rene L Olvera, Peter T Fox, John Blangero, David C. Glahn

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Working memory performance is significantly influenced by genetic factors. Here, we assessed genetic contributions to both working memory performance and neuroimaging measures focused on the network of brain regions associated with working memory by using a sample of 467 human participants from extended families. Imaging measures included diffusion tensor imaging indices in major white matter tracts thought to be associated with working memory and structural magnetic resonance imaging measures of frontal and parietal gray matter density. Analyses directly addressed whether workingmemoryperformance and neural structural integrity are influenced by common genetic factors (e.g., pleiotropy). While all cognitive measures, gray matter regions, and white matter tracts assessed were heritable, only performance on a spatial delayed response task and integrity of the superior longitudinal fasciculus (a primary frontoparietal connection) shared genetic factors. As working memory may be a core component of other higher level processes, such as general intelligence, this finding has implications for the heritability of complex cognitive functions, as well as for our understanding of the transmission of cognitive deficits in mental and neurological disorders.

Original languageEnglish (US)
Pages (from-to)8197-8202
Number of pages6
JournalJournal of Neuroscience
Volume30
Issue number24
DOIs
StatePublished - Jun 16 2010

Fingerprint

Short-Term Memory
Diffusion Tensor Imaging
Nervous System Diseases
Intelligence
Mental Disorders
Neuroimaging
Cognition
Magnetic Resonance Imaging
Brain
Gray Matter
White Matter

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Karlsgodt, K. H., Kochunov, P., Winkler, A. M., Laird, A. R., Almasy, L., Duggirala, R., ... Glahn, D. C. (2010). A multimodal assessment of the genetic control over working memory. Journal of Neuroscience, 30(24), 8197-8202. https://doi.org/10.1523/JNEUROSCI.0359-10.2010

A multimodal assessment of the genetic control over working memory. / Karlsgodt, Katherine H.; Kochunov, Peter; Winkler, Anderson M.; Laird, Angela R.; Almasy, Laura; Duggirala, Ravindranath; Olvera, Rene L; Fox, Peter T; Blangero, John; Glahn, David C.

In: Journal of Neuroscience, Vol. 30, No. 24, 16.06.2010, p. 8197-8202.

Research output: Contribution to journalArticle

Karlsgodt, KH, Kochunov, P, Winkler, AM, Laird, AR, Almasy, L, Duggirala, R, Olvera, RL, Fox, PT, Blangero, J & Glahn, DC 2010, 'A multimodal assessment of the genetic control over working memory', Journal of Neuroscience, vol. 30, no. 24, pp. 8197-8202. https://doi.org/10.1523/JNEUROSCI.0359-10.2010
Karlsgodt KH, Kochunov P, Winkler AM, Laird AR, Almasy L, Duggirala R et al. A multimodal assessment of the genetic control over working memory. Journal of Neuroscience. 2010 Jun 16;30(24):8197-8202. https://doi.org/10.1523/JNEUROSCI.0359-10.2010
Karlsgodt, Katherine H. ; Kochunov, Peter ; Winkler, Anderson M. ; Laird, Angela R. ; Almasy, Laura ; Duggirala, Ravindranath ; Olvera, Rene L ; Fox, Peter T ; Blangero, John ; Glahn, David C. / A multimodal assessment of the genetic control over working memory. In: Journal of Neuroscience. 2010 ; Vol. 30, No. 24. pp. 8197-8202.
@article{b34817f401a04d63b2e724c2dec2e970,
title = "A multimodal assessment of the genetic control over working memory",
abstract = "Working memory performance is significantly influenced by genetic factors. Here, we assessed genetic contributions to both working memory performance and neuroimaging measures focused on the network of brain regions associated with working memory by using a sample of 467 human participants from extended families. Imaging measures included diffusion tensor imaging indices in major white matter tracts thought to be associated with working memory and structural magnetic resonance imaging measures of frontal and parietal gray matter density. Analyses directly addressed whether workingmemoryperformance and neural structural integrity are influenced by common genetic factors (e.g., pleiotropy). While all cognitive measures, gray matter regions, and white matter tracts assessed were heritable, only performance on a spatial delayed response task and integrity of the superior longitudinal fasciculus (a primary frontoparietal connection) shared genetic factors. As working memory may be a core component of other higher level processes, such as general intelligence, this finding has implications for the heritability of complex cognitive functions, as well as for our understanding of the transmission of cognitive deficits in mental and neurological disorders.",
author = "Karlsgodt, {Katherine H.} and Peter Kochunov and Winkler, {Anderson M.} and Laird, {Angela R.} and Laura Almasy and Ravindranath Duggirala and Olvera, {Rene L} and Fox, {Peter T} and John Blangero and Glahn, {David C.}",
year = "2010",
month = "6",
day = "16",
doi = "10.1523/JNEUROSCI.0359-10.2010",
language = "English (US)",
volume = "30",
pages = "8197--8202",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "24",

}

TY - JOUR

T1 - A multimodal assessment of the genetic control over working memory

AU - Karlsgodt, Katherine H.

AU - Kochunov, Peter

AU - Winkler, Anderson M.

AU - Laird, Angela R.

AU - Almasy, Laura

AU - Duggirala, Ravindranath

AU - Olvera, Rene L

AU - Fox, Peter T

AU - Blangero, John

AU - Glahn, David C.

PY - 2010/6/16

Y1 - 2010/6/16

N2 - Working memory performance is significantly influenced by genetic factors. Here, we assessed genetic contributions to both working memory performance and neuroimaging measures focused on the network of brain regions associated with working memory by using a sample of 467 human participants from extended families. Imaging measures included diffusion tensor imaging indices in major white matter tracts thought to be associated with working memory and structural magnetic resonance imaging measures of frontal and parietal gray matter density. Analyses directly addressed whether workingmemoryperformance and neural structural integrity are influenced by common genetic factors (e.g., pleiotropy). While all cognitive measures, gray matter regions, and white matter tracts assessed were heritable, only performance on a spatial delayed response task and integrity of the superior longitudinal fasciculus (a primary frontoparietal connection) shared genetic factors. As working memory may be a core component of other higher level processes, such as general intelligence, this finding has implications for the heritability of complex cognitive functions, as well as for our understanding of the transmission of cognitive deficits in mental and neurological disorders.

AB - Working memory performance is significantly influenced by genetic factors. Here, we assessed genetic contributions to both working memory performance and neuroimaging measures focused on the network of brain regions associated with working memory by using a sample of 467 human participants from extended families. Imaging measures included diffusion tensor imaging indices in major white matter tracts thought to be associated with working memory and structural magnetic resonance imaging measures of frontal and parietal gray matter density. Analyses directly addressed whether workingmemoryperformance and neural structural integrity are influenced by common genetic factors (e.g., pleiotropy). While all cognitive measures, gray matter regions, and white matter tracts assessed were heritable, only performance on a spatial delayed response task and integrity of the superior longitudinal fasciculus (a primary frontoparietal connection) shared genetic factors. As working memory may be a core component of other higher level processes, such as general intelligence, this finding has implications for the heritability of complex cognitive functions, as well as for our understanding of the transmission of cognitive deficits in mental and neurological disorders.

UR - http://www.scopus.com/inward/record.url?scp=77953736229&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953736229&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.0359-10.2010

DO - 10.1523/JNEUROSCI.0359-10.2010

M3 - Article

VL - 30

SP - 8197

EP - 8202

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 24

ER -