A Multifactor Approach to Mild Cognitive Impairment

Taha Qarni, Arash Salardini

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Mild cognitive impairment (MCI) represents an intermediate stage between normal cognition and dementia. Individuals with MCI are at increased risk of conversion to dementia, and the rate of progression of MCI to dementia is dependent on age, gender, and education. MCI may be diagnosed using neuropsychological criteria using cut-offs representing decrements in cognition, or using criteria to assess for a decline in functional status. The ability to determine the status of dementia-related biomarkers has allowed for better staging and prognostication in different forms of MCI. MCI is now recognized as a significant target stage for future therapies. These future therapies aim to reduce the rate of conversion of individuals with MCI to dementia. In this article, we review different conceptions of MCI, the diagnosis and prognostication of MCI, and presently available management approaches for this condition.

Original languageEnglish (US)
Pages (from-to)179-187
Number of pages9
JournalSeminars in Neurology
Issue number2
StatePublished - 2019
Externally publishedYes


  • dementia
  • MCI
  • mild cognitive impairment

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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