A ML29 reassortant virus protects guinea pigs against a distantly related Nigerian strain of Lassa virus and can provide sterilizing immunity

Ricardo Carrion, Jean L. Patterson, Curtis Johnson, Monica Gonzales, Carmen R. Moreira, Anysha Ticer, Kathleen Brasky, Gene B. Hubbard, Dmitry Moshkoff, Juan Zapata, Maria S. Salvato, Igor S. Lukashevich

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

Lassa virus (LASV) is responsible for the deaths of thousands of people in West Africa annually. Genetic diversity among LASV strains is the highest among the Arenaviridae and represents a great challenge for vaccine development. Guinea pigs vaccinated with a ML29 reassortant vaccine experienced sterilizing immunity and complete protection when challenged on day 30 either with homologous virus or with the distantly related Nigerian isolate. Simultaneous vaccination-challenge or challenge on day 2 after vaccination also protected 60-100% of the animals against both strains, but without sterilizing immunity. These results indicate that simultaneous replication of ML29 and LASV attenuates the virulence of LASV infection.

Original languageEnglish (US)
Pages (from-to)4093-4102
Number of pages10
JournalVaccine
Volume25
Issue number20
DOIs
StatePublished - May 16 2007

Keywords

  • Cross-protection
  • Lassa fever
  • Reassortant vaccine
  • Sterilizing immunity

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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