A ML29 reassortant virus protects guinea pigs against a distantly related Nigerian strain of Lassa virus and can provide sterilizing immunity

Ricardo Carrion, Jean L. Patterson, Curtis Johnson, Monica Gonzales, Carmen R. Moreira, Anysha Ticer, Kathleen Brasky, Gene B. Hubbard, Dmitry Moshkoff, Juan Zapata, Maria S. Salvato, Igor S. Lukashevich

    Research output: Contribution to journalArticle

    55 Scopus citations

    Abstract

    Lassa virus (LASV) is responsible for the deaths of thousands of people in West Africa annually. Genetic diversity among LASV strains is the highest among the Arenaviridae and represents a great challenge for vaccine development. Guinea pigs vaccinated with a ML29 reassortant vaccine experienced sterilizing immunity and complete protection when challenged on day 30 either with homologous virus or with the distantly related Nigerian isolate. Simultaneous vaccination-challenge or challenge on day 2 after vaccination also protected 60-100% of the animals against both strains, but without sterilizing immunity. These results indicate that simultaneous replication of ML29 and LASV attenuates the virulence of LASV infection.

    Original languageEnglish (US)
    Pages (from-to)4093-4102
    Number of pages10
    JournalVaccine
    Volume25
    Issue number20
    DOIs
    StatePublished - May 16 2007

    Keywords

    • Cross-protection
    • Lassa fever
    • Reassortant vaccine
    • Sterilizing immunity

    ASJC Scopus subject areas

    • Molecular Medicine
    • Immunology and Microbiology(all)
    • veterinary(all)
    • Public Health, Environmental and Occupational Health
    • Infectious Diseases

    Fingerprint Dive into the research topics of 'A ML29 reassortant virus protects guinea pigs against a distantly related Nigerian strain of Lassa virus and can provide sterilizing immunity'. Together they form a unique fingerprint.

  • Cite this

    Carrion, R., Patterson, J. L., Johnson, C., Gonzales, M., Moreira, C. R., Ticer, A., Brasky, K., Hubbard, G. B., Moshkoff, D., Zapata, J., Salvato, M. S., & Lukashevich, I. S. (2007). A ML29 reassortant virus protects guinea pigs against a distantly related Nigerian strain of Lassa virus and can provide sterilizing immunity. Vaccine, 25(20), 4093-4102. https://doi.org/10.1016/j.vaccine.2007.02.038