A microdialysis study on the mechanism of action of gabapentin

Wia Timmerman; Marielle Bouma; Jan B. De Vries; Michael Davis; Ben H.C. Westerink

doi:10.1016/S0014-2999(00)00309-5

A microdialysis study on the mechanism of action of gabapentin

Wia Timmerman, Marielle Bouma, Jan B. De Vries, Michael Davis, Ben H.C. Westerink

Pharmacology

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

To gain insight into the mechanism of action of the anti-epileptic, gabapentin, the effects of gabapentin on the in vivo extracellular γ- aminobutyric acid (GABA) levels in the rat substantia nigra reticulata were studied using microdialysis. In order to investigate possible interference with different GABA-ergic compartments in the substantia nigra reticulata, we studied the effects of gabapentin under basal, K⁺-, nipecotic acid- and glutamate-stimulated conditions. Intraperitoneally (i.p.) administered gabapentin, at a dose of 100 mg/kg, did not significantly affect extracellular GABA levels under any condition. Thus, our data do not support the involvement of nigral GABA release in the mechanism of action of the anti-epileptic gabapentin. (C) 2000 Elsevier Science B.V.

Original language	English (US)
Pages (from-to)	53-57
Number of pages	5
Journal	European Journal of Pharmacology
Volume	398
Issue number	1
DOIs	https://doi.org/10.1016/S0014-2999(00)00309-5
State	Published - Jun 9 2000

Keywords

Gabapentin
Microdialysis
Substantia nigra reticulata
γ-Aminobutyric acid

ASJC Scopus subject areas

Pharmacology

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10.1016/S0014-2999(00)00309-5

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title = "A microdialysis study on the mechanism of action of gabapentin",

abstract = "To gain insight into the mechanism of action of the anti-epileptic, gabapentin, the effects of gabapentin on the in vivo extracellular γ- aminobutyric acid (GABA) levels in the rat substantia nigra reticulata were studied using microdialysis. In order to investigate possible interference with different GABA-ergic compartments in the substantia nigra reticulata, we studied the effects of gabapentin under basal, K+-, nipecotic acid- and glutamate-stimulated conditions. Intraperitoneally (i.p.) administered gabapentin, at a dose of 100 mg/kg, did not significantly affect extracellular GABA levels under any condition. Thus, our data do not support the involvement of nigral GABA release in the mechanism of action of the anti-epileptic gabapentin. (C) 2000 Elsevier Science B.V.",

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AU - Timmerman, Wia

AU - Bouma, Marielle

AU - De Vries, Jan B.

AU - Davis, Michael

AU - Westerink, Ben H.C.

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N2 - To gain insight into the mechanism of action of the anti-epileptic, gabapentin, the effects of gabapentin on the in vivo extracellular γ- aminobutyric acid (GABA) levels in the rat substantia nigra reticulata were studied using microdialysis. In order to investigate possible interference with different GABA-ergic compartments in the substantia nigra reticulata, we studied the effects of gabapentin under basal, K+-, nipecotic acid- and glutamate-stimulated conditions. Intraperitoneally (i.p.) administered gabapentin, at a dose of 100 mg/kg, did not significantly affect extracellular GABA levels under any condition. Thus, our data do not support the involvement of nigral GABA release in the mechanism of action of the anti-epileptic gabapentin. (C) 2000 Elsevier Science B.V.

AB - To gain insight into the mechanism of action of the anti-epileptic, gabapentin, the effects of gabapentin on the in vivo extracellular γ- aminobutyric acid (GABA) levels in the rat substantia nigra reticulata were studied using microdialysis. In order to investigate possible interference with different GABA-ergic compartments in the substantia nigra reticulata, we studied the effects of gabapentin under basal, K+-, nipecotic acid- and glutamate-stimulated conditions. Intraperitoneally (i.p.) administered gabapentin, at a dose of 100 mg/kg, did not significantly affect extracellular GABA levels under any condition. Thus, our data do not support the involvement of nigral GABA release in the mechanism of action of the anti-epileptic gabapentin. (C) 2000 Elsevier Science B.V.

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KW - Substantia nigra reticulata

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