A microdialysis study on the mechanism of action of gabapentin

Wia Timmerman, Marielle Bouma, Jan B. De Vries, Michael Davis, Ben H.C. Westerink

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12 Scopus citations

Abstract

To gain insight into the mechanism of action of the anti-epileptic, gabapentin, the effects of gabapentin on the in vivo extracellular γ- aminobutyric acid (GABA) levels in the rat substantia nigra reticulata were studied using microdialysis. In order to investigate possible interference with different GABA-ergic compartments in the substantia nigra reticulata, we studied the effects of gabapentin under basal, K+-, nipecotic acid- and glutamate-stimulated conditions. Intraperitoneally (i.p.) administered gabapentin, at a dose of 100 mg/kg, did not significantly affect extracellular GABA levels under any condition. Thus, our data do not support the involvement of nigral GABA release in the mechanism of action of the anti-epileptic gabapentin. (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)53-57
Number of pages5
JournalEuropean Journal of Pharmacology
Volume398
Issue number1
DOIs
StatePublished - Jun 9 2000

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Keywords

  • Gabapentin
  • Microdialysis
  • Substantia nigra reticulata
  • γ-Aminobutyric acid

ASJC Scopus subject areas

  • Pharmacology

Cite this

Timmerman, W., Bouma, M., De Vries, J. B., Davis, M., & Westerink, B. H. C. (2000). A microdialysis study on the mechanism of action of gabapentin. European Journal of Pharmacology, 398(1), 53-57. https://doi.org/10.1016/S0014-2999(00)00309-5