A microdialysis study on the mechanism of action of gabapentin

Wia Timmerman; Marielle Bouma; Jan B. De Vries; Michael Davis; Ben H.C. Westerink

doi:10.1016/S0014-2999(00)00309-5

A microdialysis study on the mechanism of action of gabapentin

Wia Timmerman, Marielle Bouma, Jan B. De Vries, Michael Davis, Ben H.C. Westerink

Pharmacology

Research output: Contribution to journal › Article

12 Scopus citations

Abstract

To gain insight into the mechanism of action of the anti-epileptic, gabapentin, the effects of gabapentin on the in vivo extracellular γ- aminobutyric acid (GABA) levels in the rat substantia nigra reticulata were studied using microdialysis. In order to investigate possible interference with different GABA-ergic compartments in the substantia nigra reticulata, we studied the effects of gabapentin under basal, K⁺-, nipecotic acid- and glutamate-stimulated conditions. Intraperitoneally (i.p.) administered gabapentin, at a dose of 100 mg/kg, did not significantly affect extracellular GABA levels under any condition. Thus, our data do not support the involvement of nigral GABA release in the mechanism of action of the anti-epileptic gabapentin. (C) 2000 Elsevier Science B.V.

Original language	English (US)
Pages (from-to)	53-57
Number of pages	5
Journal	European Journal of Pharmacology
Volume	398
Issue number	1
DOIs	https://doi.org/10.1016/S0014-2999(00)00309-5
State	Published - Jun 9 2000

Fingerprint

Keywords

Gabapentin
Microdialysis
Substantia nigra reticulata
γ-Aminobutyric acid

ASJC Scopus subject areas

Pharmacology

Cite this

Timmerman, W., Bouma, M., De Vries, J. B., Davis, M., & Westerink, B. H. C. (2000). A microdialysis study on the mechanism of action of gabapentin. European Journal of Pharmacology, 398(1), 53-57. https://doi.org/10.1016/S0014-2999(00)00309-5

@article{b529cced15b748f18b36697b60776b72,

title = "A microdialysis study on the mechanism of action of gabapentin",

abstract = "To gain insight into the mechanism of action of the anti-epileptic, gabapentin, the effects of gabapentin on the in vivo extracellular γ- aminobutyric acid (GABA) levels in the rat substantia nigra reticulata were studied using microdialysis. In order to investigate possible interference with different GABA-ergic compartments in the substantia nigra reticulata, we studied the effects of gabapentin under basal, K+-, nipecotic acid- and glutamate-stimulated conditions. Intraperitoneally (i.p.) administered gabapentin, at a dose of 100 mg/kg, did not significantly affect extracellular GABA levels under any condition. Thus, our data do not support the involvement of nigral GABA release in the mechanism of action of the anti-epileptic gabapentin. (C) 2000 Elsevier Science B.V.",

keywords = "Gabapentin, Microdialysis, Substantia nigra reticulata, γ-Aminobutyric acid",

author = "Wia Timmerman and Marielle Bouma and {De Vries}, {Jan B.} and Michael Davis and Westerink, {Ben H.C.}",

year = "2000",

month = jun

day = "9",

doi = "10.1016/S0014-2999(00)00309-5",

language = "English (US)",

volume = "398",

pages = "53--57",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - A microdialysis study on the mechanism of action of gabapentin

AU - Timmerman, Wia

AU - Bouma, Marielle

AU - De Vries, Jan B.

AU - Davis, Michael

AU - Westerink, Ben H.C.

PY - 2000/6/9

Y1 - 2000/6/9

N2 - To gain insight into the mechanism of action of the anti-epileptic, gabapentin, the effects of gabapentin on the in vivo extracellular γ- aminobutyric acid (GABA) levels in the rat substantia nigra reticulata were studied using microdialysis. In order to investigate possible interference with different GABA-ergic compartments in the substantia nigra reticulata, we studied the effects of gabapentin under basal, K+-, nipecotic acid- and glutamate-stimulated conditions. Intraperitoneally (i.p.) administered gabapentin, at a dose of 100 mg/kg, did not significantly affect extracellular GABA levels under any condition. Thus, our data do not support the involvement of nigral GABA release in the mechanism of action of the anti-epileptic gabapentin. (C) 2000 Elsevier Science B.V.

AB - To gain insight into the mechanism of action of the anti-epileptic, gabapentin, the effects of gabapentin on the in vivo extracellular γ- aminobutyric acid (GABA) levels in the rat substantia nigra reticulata were studied using microdialysis. In order to investigate possible interference with different GABA-ergic compartments in the substantia nigra reticulata, we studied the effects of gabapentin under basal, K+-, nipecotic acid- and glutamate-stimulated conditions. Intraperitoneally (i.p.) administered gabapentin, at a dose of 100 mg/kg, did not significantly affect extracellular GABA levels under any condition. Thus, our data do not support the involvement of nigral GABA release in the mechanism of action of the anti-epileptic gabapentin. (C) 2000 Elsevier Science B.V.

KW - Gabapentin

KW - Microdialysis

KW - Substantia nigra reticulata

KW - γ-Aminobutyric acid

UR - http://www.scopus.com/inward/record.url?scp=0034625644&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034625644&partnerID=8YFLogxK

U2 - 10.1016/S0014-2999(00)00309-5

DO - 10.1016/S0014-2999(00)00309-5

M3 - Article

C2 - 10856447

AN - SCOPUS:0034625644

VL - 398

SP - 53

EP - 57

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 1

ER -

Access to Document

10.1016/S0014-2999(00)00309-5