TY - JOUR
T1 - A microdialysis study on the mechanism of action of gabapentin
AU - Timmerman, Wia
AU - Bouma, Marielle
AU - De Vries, Jan B.
AU - Davis, Michael
AU - Westerink, Ben H.C.
PY - 2000/6/9
Y1 - 2000/6/9
N2 - To gain insight into the mechanism of action of the anti-epileptic, gabapentin, the effects of gabapentin on the in vivo extracellular γ- aminobutyric acid (GABA) levels in the rat substantia nigra reticulata were studied using microdialysis. In order to investigate possible interference with different GABA-ergic compartments in the substantia nigra reticulata, we studied the effects of gabapentin under basal, K+-, nipecotic acid- and glutamate-stimulated conditions. Intraperitoneally (i.p.) administered gabapentin, at a dose of 100 mg/kg, did not significantly affect extracellular GABA levels under any condition. Thus, our data do not support the involvement of nigral GABA release in the mechanism of action of the anti-epileptic gabapentin. (C) 2000 Elsevier Science B.V.
AB - To gain insight into the mechanism of action of the anti-epileptic, gabapentin, the effects of gabapentin on the in vivo extracellular γ- aminobutyric acid (GABA) levels in the rat substantia nigra reticulata were studied using microdialysis. In order to investigate possible interference with different GABA-ergic compartments in the substantia nigra reticulata, we studied the effects of gabapentin under basal, K+-, nipecotic acid- and glutamate-stimulated conditions. Intraperitoneally (i.p.) administered gabapentin, at a dose of 100 mg/kg, did not significantly affect extracellular GABA levels under any condition. Thus, our data do not support the involvement of nigral GABA release in the mechanism of action of the anti-epileptic gabapentin. (C) 2000 Elsevier Science B.V.
KW - Gabapentin
KW - Microdialysis
KW - Substantia nigra reticulata
KW - γ-Aminobutyric acid
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U2 - 10.1016/S0014-2999(00)00309-5
DO - 10.1016/S0014-2999(00)00309-5
M3 - Article
C2 - 10856447
AN - SCOPUS:0034625644
VL - 398
SP - 53
EP - 57
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1
ER -