A method for the determination of sodium, potassium, magnesium and lithium concentrations in erythrocytes

Alan Frazer; Steven K. Secunda; Joe Mendels

doi:10.1016/0009-8981(72)90026-5

A method for the determination of sodium, potassium, magnesium and lithium concentrations in erythrocytes

Alan Frazer
, Steven K. Secunda
, Joe Mendels

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

A technique for the rapid and accurate estimation of intra-erythrocyte concentrations of Na, K, Li and Mg is described. CoEDTA is used as a marker to estimate plasma trapped in the red cell column ; the use of this compound constitutes a novel departure from other marker substances previously used. Plasma trapping was found to average close to 3% (v/v) of the packed cell column. RBC electrolyte values obtained from healthy control subjects were shown to be in good agreement with values reported in the literature.

Original language	English (US)
Pages (from-to)	499-509
Number of pages	11
Journal	Clinica Chimica Acta
Volume	36
Issue number	2
DOIs	https://doi.org/10.1016/0009-8981(72)90026-5
State	Published - Feb 1972
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, medical
Biochemistry
Clinical Biochemistry

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10.1016/0009-8981(72)90026-5

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title = "A method for the determination of sodium, potassium, magnesium and lithium concentrations in erythrocytes",

abstract = "A technique for the rapid and accurate estimation of intra-erythrocyte concentrations of Na, K, Li and Mg is described. CoEDTA is used as a marker to estimate plasma trapped in the red cell column ; the use of this compound constitutes a novel departure from other marker substances previously used. Plasma trapping was found to average close to 3\% (v/v) of the packed cell column. RBC electrolyte values obtained from healthy control subjects were shown to be in good agreement with values reported in the literature.",

author = "Alan Frazer and Secunda, \{Steven K.\} and Joe Mendels",

note = "Funding Information: * This research was supported by Fart I research funds from the Veterans Administration NIMH grant \# I Ro3 MHr6gzo MSM. ** Present address: National Institute of Mental Health. Koclwille, Maryland.",

year = "1972",

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doi = "10.1016/0009-8981(72)90026-5",

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T1 - A method for the determination of sodium, potassium, magnesium and lithium concentrations in erythrocytes

AU - Frazer, Alan

AU - Secunda, Steven K.

AU - Mendels, Joe

N1 - Funding Information: * This research was supported by Fart I research funds from the Veterans Administration NIMH grant # I Ro3 MHr6gzo MSM. ** Present address: National Institute of Mental Health. Koclwille, Maryland.

PY - 1972/2

Y1 - 1972/2

N2 - A technique for the rapid and accurate estimation of intra-erythrocyte concentrations of Na, K, Li and Mg is described. CoEDTA is used as a marker to estimate plasma trapped in the red cell column ; the use of this compound constitutes a novel departure from other marker substances previously used. Plasma trapping was found to average close to 3% (v/v) of the packed cell column. RBC electrolyte values obtained from healthy control subjects were shown to be in good agreement with values reported in the literature.

AB - A technique for the rapid and accurate estimation of intra-erythrocyte concentrations of Na, K, Li and Mg is described. CoEDTA is used as a marker to estimate plasma trapped in the red cell column ; the use of this compound constitutes a novel departure from other marker substances previously used. Plasma trapping was found to average close to 3% (v/v) of the packed cell column. RBC electrolyte values obtained from healthy control subjects were shown to be in good agreement with values reported in the literature.

UR - https://www.scopus.com/pages/publications/0015295680

UR - https://www.scopus.com/pages/publications/0015295680#tab=citedBy

U2 - 10.1016/0009-8981(72)90026-5

DO - 10.1016/0009-8981(72)90026-5

M3 - Article

C2 - 4621509

AN - SCOPUS:0015295680

SN - 0009-8981

VL - 36

SP - 499

EP - 509

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

IS - 2

ER -

A method for the determination of sodium, potassium, magnesium and lithium concentrations in erythrocytes

Abstract

ASJC Scopus subject areas

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