A method for the determination of sodium, potassium, magnesium and lithium concentrations in erythrocytes

Alan Frazer, Steven K. Secunda, Joe Mendels

Research output: Contribution to journalArticle

39 Scopus citations


A technique for the rapid and accurate estimation of intra-erythrocyte concentrations of Na, K, Li and Mg is described. CoEDTA is used as a marker to estimate plasma trapped in the red cell column ; the use of this compound constitutes a novel departure from other marker substances previously used. Plasma trapping was found to average close to 3% (v/v) of the packed cell column. RBC electrolyte values obtained from healthy control subjects were shown to be in good agreement with values reported in the literature.

Original languageEnglish (US)
Pages (from-to)499-509
Number of pages11
JournalClinica Chimica Acta
Issue number2
Publication statusPublished - Feb 1972


ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

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