A metabolite-GWAS (mGWAS) approach to unveil chronic kidney disease progression

Guanshi Zhang, Rintaro Saito, Kumar Sharma

Research output: Contribution to journalComment/debate

2 Citations (Scopus)

Abstract

In this issue, McMahon et al. report that, by combining phenotypic, metabolomic, and genetic data, they could better detect chronic kidney disease at the early stages and provide insight into its pathobiology. The most significant findings of the study are that several urinary metabolites (e.g., glycine and histidine) were identified as early risk factors for chronic kidney disease, and metabolites with genomewide association study analysis identified associations of urinary metabolites (i.e., lysine and NG-monomethyl-L-arginine) with single-nucleotide polymorphisms of SLC7A9.

Original languageEnglish (US)
Pages (from-to)1274-1276
Number of pages3
JournalKidney International
Volume91
Issue number6
DOIs
StatePublished - Jun 1 2017
Externally publishedYes

Fingerprint

Genome-Wide Association Study
Chronic Renal Insufficiency
Disease Progression
omega-N-Methylarginine
Metabolomics
Histidine
Glycine
Lysine
Single Nucleotide Polymorphism

ASJC Scopus subject areas

  • Nephrology

Cite this

A metabolite-GWAS (mGWAS) approach to unveil chronic kidney disease progression. / Zhang, Guanshi; Saito, Rintaro; Sharma, Kumar.

In: Kidney International, Vol. 91, No. 6, 01.06.2017, p. 1274-1276.

Research output: Contribution to journalComment/debate

Zhang, Guanshi ; Saito, Rintaro ; Sharma, Kumar. / A metabolite-GWAS (mGWAS) approach to unveil chronic kidney disease progression. In: Kidney International. 2017 ; Vol. 91, No. 6. pp. 1274-1276.
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