A meta-analysis on neural changes of cognitive training for mental disorders in executive function tasks: increase or decrease brain activation?

Jin Yang Li, Huiqin Wu, Shiting Yuan, Chun Wang, Qian Wang, Yuan Zhong, Ning Zhang, Kathi Heffner, Peter T. Fox

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Cognitive impairment is often found in patients with psychiatric disorders, and cognitive training (CT) has been shown to help these patients. To better understand the mechanisms of CT, many neuroimaging studies have investigated the neural changes associated with it. However, the results of those studies have been inconsistent, making it difficult to draw conclusions from the literature. Therefore, the objective of this meta-analysis was to identify consistent patterns in the literature of neural changes associated with CT for psychiatric disorders. Methods: We searched for cognitive training imaging studies in PubMed, Cochrane library, Scopus, and ProQuest electronic databases. We conducted an activation likelihood estimation (ALE) for coordinate-based meta-analysis of neuroimaging studies, conduct behavioral analysis of brain regions identified by ALE analysis, conduct behavioral analysis of brain regions identified by ALE analysis, and then created a functional meta-analytic connectivity model (fMACM) of the resulting regions. Results: Results showed that CT studies consistently reported increased activation in the left inferior frontal gyrus (IFG) and decreased activation in the left precuneus and cuneus from pre- to post- CT. Conclusion: CT improves cognitive function by supporting language and memory function, and reducing neuronal resources associated with basic visual processing.

Original languageEnglish (US)
Article number155
JournalBMC Psychiatry
Volume22
Issue number1
DOIs
StatePublished - Dec 2022

Keywords

  • Cognitive training
  • Mental disorder
  • Meta-analysis
  • Neuroimaging

ASJC Scopus subject areas

  • Psychiatry and Mental health

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