A Meta-Analysis of Postoperative Radiotherapy for Thymic Carcinoma

Masatsugu Hamaji; Rohan M. Shah; Syed Osman Ali; Aaron Bettenhausen; Hyun Sung Lee; Bryan M. Burt

doi:10.1016/j.athoracsur.2016.12.042

A Meta-Analysis of Postoperative Radiotherapy for Thymic Carcinoma

Masatsugu Hamaji, Rohan M. Shah, Syed Osman Ali, Aaron Bettenhausen, Hyun Sung Lee, Bryan M. Burt

Department of Cardiothoracic Surgery

Research output: Contribution to journal › Review article › peer-review

38 Scopus citations

Abstract

Postoperative radiotherapy may significantly improve survival of patients undergoing surgery for thymic carcinoma; however, the quality of available evidence is low. We performed a meta-analysis encompassing 973 patients to investigate the effect of postoperative radiotherapy on survival outcomes of thymic carcinoma, and included our analysis of the Surveillance, Epidemiology, and End Results database. The pooled hazard ratio of postoperative radiotherapy was 0.66 (95% confidence interval: 0.54 to 0.80, p < 0.001) for overall survival and 0.54 (95% confidence interval: 0.41 to 0.71, p < 0.001) for progression-free survival. The balance of best available evidence suggests that postoperative radiotherapy after resection of thymic carcinoma is associated with improved overall and progression-free survival.

Original language	English (US)
Pages (from-to)	1668-1675
Number of pages	8
Journal	Annals of Thoracic Surgery
Volume	103
Issue number	5
DOIs	https://doi.org/10.1016/j.athoracsur.2016.12.042
State	Published - May 2017

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Pulmonary and Respiratory Medicine
Surgery

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10.1016/j.athoracsur.2016.12.042

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title = "A Meta-Analysis of Postoperative Radiotherapy for Thymic Carcinoma",

abstract = "Postoperative radiotherapy may significantly improve survival of patients undergoing surgery for thymic carcinoma; however, the quality of available evidence is low. We performed a meta-analysis encompassing 973 patients to investigate the effect of postoperative radiotherapy on survival outcomes of thymic carcinoma, and included our analysis of the Surveillance, Epidemiology, and End Results database. The pooled hazard ratio of postoperative radiotherapy was 0.66 (95% confidence interval: 0.54 to 0.80, p < 0.001) for overall survival and 0.54 (95% confidence interval: 0.41 to 0.71, p < 0.001) for progression-free survival. The balance of best available evidence suggests that postoperative radiotherapy after resection of thymic carcinoma is associated with improved overall and progression-free survival.",

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AU - Bettenhausen, Aaron

AU - Lee, Hyun Sung

AU - Burt, Bryan M.

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AB - Postoperative radiotherapy may significantly improve survival of patients undergoing surgery for thymic carcinoma; however, the quality of available evidence is low. We performed a meta-analysis encompassing 973 patients to investigate the effect of postoperative radiotherapy on survival outcomes of thymic carcinoma, and included our analysis of the Surveillance, Epidemiology, and End Results database. The pooled hazard ratio of postoperative radiotherapy was 0.66 (95% confidence interval: 0.54 to 0.80, p < 0.001) for overall survival and 0.54 (95% confidence interval: 0.41 to 0.71, p < 0.001) for progression-free survival. The balance of best available evidence suggests that postoperative radiotherapy after resection of thymic carcinoma is associated with improved overall and progression-free survival.

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A Meta-Analysis of Postoperative Radiotherapy for Thymic Carcinoma

Abstract

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