A Meta-Analysis of Postoperative Radiotherapy for Thymic Carcinoma

Masatsugu Hamaji, Rohan M. Shah, Syed Osman Ali, Aaron Bettenhausen, Hyun Sung Lee, Bryan M. Burt

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

Postoperative radiotherapy may significantly improve survival of patients undergoing surgery for thymic carcinoma; however, the quality of available evidence is low. We performed a meta-analysis encompassing 973 patients to investigate the effect of postoperative radiotherapy on survival outcomes of thymic carcinoma, and included our analysis of the Surveillance, Epidemiology, and End Results database. The pooled hazard ratio of postoperative radiotherapy was 0.66 (95% confidence interval: 0.54 to 0.80, p < 0.001) for overall survival and 0.54 (95% confidence interval: 0.41 to 0.71, p < 0.001) for progression-free survival. The balance of best available evidence suggests that postoperative radiotherapy after resection of thymic carcinoma is associated with improved overall and progression-free survival.

Original languageEnglish (US)
Pages (from-to)1668-1675
Number of pages8
JournalAnnals of Thoracic Surgery
Volume103
Issue number5
DOIs
StatePublished - May 2017

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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