TY - JOUR
T1 - A major susceptibility locus influencing plasma triglyceride concentrations is located chromosome 15q in Mexican Americans
AU - Duggirala, Ravindranath
AU - Blangero, John
AU - Almasy, Laura
AU - Dyer, Thomas D.
AU - Williams, Kenneth L.
AU - Leach, Robin J.
AU - O'Connell, Peter
AU - Stern, Michael P.
N1 - Funding Information:
We wish to thank Dr. Mary Pat Moyer and Ms. Florence Wall for establishing some of the lymphoblastoid cell lines. We also wish to thank Rajeswari Cheruvu, Edgardo Benavides, Stefenie Fleming, Michelle Zavala, and Bonnie Reus for technical assistance. We warmly thank members of the SAFADS families for their support and participation. This research was supported by grants from the National Institute of Diabetes, Digestive and Kidney Diseases (RO1 DK42273, RO1 DK47482, and RO1 DK53889), and by grants GM18897 and MH59490 from the National Institutes of Health.
PY - 2000
Y1 - 2000
N2 - Although several genetic forms of rare or syndromic hypertriglyceridemia have been reported, little is known about the specific chromosomal regions across the genome harboring susceptibility genes for common forms of hypertriglyceridemia. Therefore, we conducted a genomewide scan for susceptibility genes influencing plasma triglyceride (TG) levels in a Mexican American population. We used both phenotypic and genotypic data from 418 individuals distributed across 27 low-income, extended Mexican American families. For the analyses, TG values were log transformed (ln TG). We used a variance-components technique to conduct multipoint linkage analyses for localizing susceptibility genes that determine variation in TG levels. We used an ~10-15-cM map, which was made on the basis of information from 295 microsatellite markers. After accounting for the effects of sex and sex- specific age terms, we found significant evidence for linkage (LOD = 3.88) of ln TG levels to a genetic location between the markers GABRB3 and D15S165 on chromosome 15q. This putative locus explains 39.7 ± 7% (P = .000012) of total phenotypic variation in ln TG levels. Suggestive evidence was found for linkage of ln TG levels to two different locations on chromosome 7, which are ~85 cM apart from each other. Also, there is some evidence for linkage of high-density lipoprotein cholesterol concentrations to a genetic location near one of the regions on chromosome 7. In conclusion, we found strong evidence for linkage of ln TG levels to a genetic location on chromosome 15q in a Mexican American population, which is prone to disease conditions such as type 2 diabetes and the insulin-resistance syndrome that are associated with hypertriglyceridemia. This putative locus appears to have a major influence on ln TG variation.
AB - Although several genetic forms of rare or syndromic hypertriglyceridemia have been reported, little is known about the specific chromosomal regions across the genome harboring susceptibility genes for common forms of hypertriglyceridemia. Therefore, we conducted a genomewide scan for susceptibility genes influencing plasma triglyceride (TG) levels in a Mexican American population. We used both phenotypic and genotypic data from 418 individuals distributed across 27 low-income, extended Mexican American families. For the analyses, TG values were log transformed (ln TG). We used a variance-components technique to conduct multipoint linkage analyses for localizing susceptibility genes that determine variation in TG levels. We used an ~10-15-cM map, which was made on the basis of information from 295 microsatellite markers. After accounting for the effects of sex and sex- specific age terms, we found significant evidence for linkage (LOD = 3.88) of ln TG levels to a genetic location between the markers GABRB3 and D15S165 on chromosome 15q. This putative locus explains 39.7 ± 7% (P = .000012) of total phenotypic variation in ln TG levels. Suggestive evidence was found for linkage of ln TG levels to two different locations on chromosome 7, which are ~85 cM apart from each other. Also, there is some evidence for linkage of high-density lipoprotein cholesterol concentrations to a genetic location near one of the regions on chromosome 7. In conclusion, we found strong evidence for linkage of ln TG levels to a genetic location on chromosome 15q in a Mexican American population, which is prone to disease conditions such as type 2 diabetes and the insulin-resistance syndrome that are associated with hypertriglyceridemia. This putative locus appears to have a major influence on ln TG variation.
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U2 - 10.1086/302849
DO - 10.1086/302849
M3 - Article
C2 - 10729112
AN - SCOPUS:0033942570
SN - 0002-9297
VL - 66
SP - 1237
EP - 1245
JO - American Journal of Human Genetics
JF - American Journal of Human Genetics
IS - 4
ER -