A low-dose arsenic-induced p53 protein-mediated metabolic mechanism of radiotherapy protection

Suthakar Ganapathy, Shaowen Xiao, Mei Yang, Min Qi, Doo Eun Choi, Chul S. Ha, John B. Little, Zhi Min Yuan

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Background: Radiotherapy protection depends on a selective protection of normal tissues but not tumors. Results: We demonstrate that low doses of arsenic induce a p53/HIF-1-dependent metabolic reprogramming specific to normal cells, resulting in increased resistance to radiation toxicity. Conclusion: p53-mediated metabolic reprogramming can be explored for normal tissue protection. Significance: The use of low-dose arsenic for selective protection of normal tissues may have important therapeutic implications.

Original languageEnglish (US)
Pages (from-to)5340-5347
Number of pages8
JournalJournal of Biological Chemistry
Volume289
Issue number8
DOIs
StatePublished - Feb 21 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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